57370-28-2Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular docking studies of 2-piperazin-1-yl-quinazolines as platelet aggregation inhibitors and ligands of integrin αIIbβ3
Krysko, Andrei A.,Kornylov, Alexander Yu.,Polishchuk, Pavel G.,Samoylenko, Georgiy V.,Krysko, Olga L.,Kabanova, Tatyana A.,Kravtsov, Victor Ch.,Kabanov, Vladimir M.,Wicher, Barbara,Andronati, Sergei A.
, p. 1839 - 1843 (2016)
A series of 2-piperazin-1-yl-quinazolines were synthesized and evaluated for their antiaggregative activity. The synthesized small molecule compounds have potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to αIIbβ3integrin in a suspension of washed human platelets. The key αIIbβ3protein–ligand interactions were determined in docking experiments and some correlations have been observed between values of the affinity and docking scores.
