573764-86-0

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 4-amino-3-methyl-2-(trifluoromethyl)(9CI) serves as a building block in the synthesis of various biologically active molecules. It is particularly instrumental in the production of fungicides and insecticides, contributing to the development of effective agricultural chemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Benzonitrile, 4-amino-3-methyl-2-(trifluoromethyl)- (9CI) is utilized for the development of new drugs. Its unique structure and functional groups make it a promising candidate for creating innovative pharmaceutical agents.
Used as a Precursor in Organic Synthesis:
Benzonitrile, 4-amino-3-methyl-2-(trifluoromethyl)(9CI) is also known for its use as a precursor in the synthesis of diverse organic compounds. Its reactivity allows for the creation of a wide range of chemical products, further expanding its applications across various industries.

Upstream product

• 112641-23-3 N-(4-Chloro-2-methyl-3-trifluoromethylphenyl)-2,2-dimethyl-propionamide 
• 13691-92-4 N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 352277-93-1 tert-butyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate 
• 573764-81-5 N-(4-Cyano-2-methyl-3-trifluoromethylphenyl)-2,2-dimethyl-propionamide 
• 546434-38-2 N-[2-methyl-3-(trifluoromethyl)phenyl]acetamide 
• 54396-44-0 2-methyl-3-trifluoromethylaniline 

Downstream Products

• 627531-79-7 4-cyano-2-methyl-3-trifluoromethylphenyl isocyanate 
• 1182367-75-4 4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile 
• 1354947-98-0 2-{[4-cyano-2-methyl-3-(trifluoromethyl)phenyl]amino}-2-oxoethyl acetate 
• 1354947-99-1 {1-[4-cyano-2-methyl-3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl acetate 
• 1354948-00-7 4-[5-(hydroxymethyl)-1H-tetrazol-1-yl]-3-methyl-2-(trifluoromethyl)benzonitrile 
• 1354948-01-8 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-3-methyl-2-(trifluoromethyl)benzonitrile 
• 1371608-78-4 C₁₄H₁₁F₃N₂O₂ 
• 1371608-75-1 4-bromo-3-methyl-2-(trifluoromethyl)benzonitrile 
• 1371608-76-2 (R)-3-methyl-4-(2-oxo-5-((trityloxy)methyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile 
• 1371608-77-3 (R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile 
• 1371608-35-3 3-methyl-4-((R)-2-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile 
• 1371608-36-4 3-methyl-4-((R)-2-oxo-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile 
• 959690-45-0 4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile 

Relevant academic research and scientific papers

ANDROGEN RECEPTOR REGULATION BY SMALL MOLECULE ENANTIOMERS

Herein is reported a class of chiral compounds with paradoxical effects on the androgen receptor (AR). The (R)-enantiomers behave like classical anti-androgens while the (S)-enantiomers activate AR signaling. In castration-resistant prostate cancer, the c

SELECTIVE ANDROGEN RECEPTOR MODULATORS

This invention provides compounds of formula I, pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type 2 diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds and intermediates useful in the preparation of same.

Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists

A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of hormone refractory prostate cancer. CH4933468 (32d) with a sulfonamide side chain not only exhibited antagonistic activity with no agonistic activity in the reporter gene assay but also inhibited the growth of bicalutamide-resistant cell lines. This compound also inhibited tumor growth of the LNCaP xenograft in mice dose-dependently.

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Pharmacokinetic studies in cynomolgus monkeys with a novel prototype selective androgen receptor modulator revealed trace amounts of an aniline fragment released through hydrolytic metabolism. This aniline fragment was determined to be mutagenic in an Ames assay. Subsequent concurrent optimization for target activity and avoidance of mutagenicity led to the identification of a pharmacologically superior clinical candidate without mutagenic potential.

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Bicyclic modulators of androgen receptor function

The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION

The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.