57380-82-2Relevant academic research and scientific papers
Synthesis of Substituted Thioamides from gem-Dibromoalkenes and Sodiumsulfide
Morri, Ashok K.,Thummala, Yadagiri,Adepu, Ramesh,Sharma, Gangavaram V. M.,Ghosh, Subhash,Doddi, Venkata Ramana
supporting information, p. 7159 - 7163 (2019/11/14)
A three-component reaction of 1,1-dibromoalkenes, sodium sulfide, and N-substituted formamide for the synthesis of disubstituted thioamides has been developed. Various dibromoalkenes were found to be compatible under these conditions and gave corresponding thioamides in good to excellent yields.
Base-Controlled Three Component Reactions of Amines, Elemental Sulfur, and Styrenes: Synthesis of Thioamides under Metal-Free Conditions
Zhang, Pingshun,Chen, Wanzhi,Liu, Miaochang,Wu, Huayue
, p. 14269 - 14276 (2018/11/25)
Three component reactions of olefins, amines, and sulfur were studied. Thioamidation of styrenes is base-controlled, and 2-phenylethanethioamides and benzothioamides were obtained selectively in the presence of two different bases. This protocol offers a simple and efficient procedure for the synthesis of thioamides.
Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides
Xu, Kai,Li, Ziyi,Cheng, Fangyuan,Zuo, Zhenzhen,Wang, Tao,Wang, Mincan,Liu, Lantao
supporting information, p. 2228 - 2231 (2018/04/30)
A novel transition-metal-free cleavage reaction of C-C triple bonds in aromatic alkynes with S8 and amides furnishes aryl thioamides in moderate to excellent yields. The remarkable features of this thioamidation include the metal-free cleavage of C-C triple bond, mild reaction conditions, as well as wide substrate scope that is particularly compatible with some internal aromatic alkynes and acetamides.
Sulfur promoted decarboxylative thioamidation of carboxylic acids using formamides as amine proxy
Kumar, Saurabh,Vanjari, Rajeshwer,Guntreddi, Tirumaleswararao,Singh, Krishna Nand
, p. 2012 - 2017 (2016/04/05)
An efficient decarboxylative thioamidation of arylacetic and cinnamic acids has been developed employing formamides as amine surrogate and sulfur as promoter. Thioamides with variant structural features are obtained under mild reaction conditions without the use of transition metal catalysts and oxidants.
Dimethylamine as the key intermediate generated in situ from dimethylformamide (DMF) for the synthesis of thioamides
Liu, Weibing,Chen, Cui,Liu, Hailing
supporting information, p. 1721 - 1726 (2016/04/10)
An improved and efficient method for the synthesis of thioamides is presented. For this transformation, dimethylamine as the key intermediate is generated in situ from dimethylformamide (DMF). All the tested substrates produced the desired products with excellent isolated yields.
Copper(II)-catalyzed reactions of dimethylformamide with phenylacetonitrile and sulfur to form N,N-dimethylthioamides
Qu, Yanyang,Li, Zhengkai,Xiang, Haifeng,Zhou, Xiangge
supporting information, p. 3141 - 3146 (2013/12/04)
Novel copper-catalyzed three-component reactions of phenylacetonitrile, sulfur and DMF (dimethyformamide) for the selective preparation of N,N-dimethylthiobenzamide and N,N-dimethyl-2-phenylethanethioamides in yields of up to 96% are described. Copyright
Dimethylammonium Dimethylcarbamate - A Useful Reagent for the Willgerodt-Kindler Reaction
Schroth, Werner,Andersch, Joerg
, p. 202 - 204 (2007/10/02)
Dimethylammonium dimethylcarbamate (dimcarb), easily accessible from dimethylamine and carbon dioxide, is a useful reagent for the Willgerodt-Kindler synthesis of N,N-dimethylthiocarboxamides.Moreover, dimcarb displays some unusual properties, and generally behaves as a preparatively useful dimethylamine source.
