57381-11-0

Usage

Uses

Used in Pharmaceutical Industry:
(4-sulfamoylphenyl)carbamodithioic acid N,N-diethylethanamine (1:1) is used as a potential medicinal compound for its possible therapeutic effects. The combination of the two compounds may provide enhanced or modified properties that could be beneficial in the development of new drugs or treatments.
Used in Organic Chemistry:
Used in Solvent Applications:
N,N-diethylethanamine, being a part of the complex, is known to be used as a solvent in various chemical processes. The combination with (4-sulfamoylphenyl)carbamodithioic acid may enhance its solvent properties, making it more effective or suitable for specific applications in the chemical industry.

Upstream product

• 75-15-0 carbon disulfide 
• 63-74-1 sulfanilamide 
• 121-44-8 triethylamine 

Downstream Products

• 51908-29-3 4-isothiocyanatobenzene sulfonamide 
• 898658-67-8 N-[4-(aminosulfonyl)phenyl]-2-benzoyl-1-hydrazinecarbothioamide 
• 891614-36-1 N-[4-(aminosulfonyl)phenyl]-2-(4-methylbenzoyl)-1-hydrazinecarbothioamide 
• 899234-72-1 N-[4-(aminosulfonyl)phenyl]-2-(4-methoxybenzoyl)-1-hydrazinecarbothioamide 
• 891624-81-0 N-[4-(aminosulfonyl)phenyl]-2-(4-fluorobenzoyl)-1-hydrazinecarbothioamide 
• 897346-03-1 N-[4-(aminosulfonyl)phenyl]-2-(4-chlorobenzoyl)-1-hydrazinecarbothioamide 
• 897347-44-3 N-[4-(aminosulfonyl)phenyl]-2-(4-bromobenzoyl)-1-hydrazinecarbothioamide 
• 1580456-62-7 2-[4-(aminosulfonyl)benzoyl]-N-[4-(aminosulfonyl)phenyl]-1-hydrazinecarbothioamide 
• 1580456-46-7 4-(3-phenyl-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)benzenesulfonamide 
• 1580456-47-8 4-[3-(4-methylphenyl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzenesulfonamide 
• 523990-78-5 4-[3-(4-methoxyphenyl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzenesulfonamide 
• 1580456-48-9 4-[3-(4-fluorophenyl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzenesulfonamide 
• 1580456-49-0 4-[3-(4-chlorophenyl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzenesulfonamide 
• 1580456-50-3 4-[3-(4-bromophenyl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]benzenesulfonamide 

Relevant academic research and scientific papers

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII

Three series of novel heterocyclic compounds (3a-3g, 4a-4g and 5a-5g) containing benzenesulfonamide moiety and incorporating a 1,2,4-triazole ring, have been synthesized and investigated as inhibitors against four isomers of the α-class carbonic anhydrases (CAs, EC 4.2.1.1), comprising hCAs I and II (cytosolic, ubiquitous isozymes) and hCAs IX and XII (transmembrane, tumor associated isozymes). Against the human isozymes hCA I and II, compounds of two series (3a-3g and 4a-4g) showed Ki values in the range of 84-868 nM and 5.6-390 nM, respectively whereas compounds of series 5a-5g were found to be poor inhibitors (Ki values exceeding 10,000 nM in some cases). Against hCA IX and XII, all the tested compounds exhibited excellent to moderate inhibitory potential with Ki values in the range of 2.8-431 nM and 1.3-63 nM, respectively. Compounds 3d, 3f and 4f exhibited excellent inhibitory potential against all of the four isozymes hCA I, II, IX and XII, even better than the standard drug acetazolamide (AZA) whereas compound of the series 5a-5g were comparatively less potent but more selective towards hCA IX and XII.