573977-51-2

Basic information

• Product Name: Piperazine, 1-(5-chloro-2,3-dihydro-3-oxo-4-pyridazinyl)-4-(2-furanylcarbonyl)-
• CAS NO: 573977-51-2
• Molecular Formula: C13H13ClN4O3
• Molecular Weight: 308.724
• Mol File: 573977-51-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(5-chloro-2,3-dihydro-3-oxo-4-pyridazinyl)-4-(2-furanylcarbonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(5-chloro-2,3-dihydro-3-oxo-4-pyridazinyl)-4-(2-furanylcarbonyl)-(573977-51-2)
• EPA Substance Registry System: Piperazine, 1-(5-chloro-2,3-dihydro-3-oxo-4-pyridazinyl)-4-(2-furanylcarbonyl)-(573977-51-2)

Safety Data

• Hazardous Substances Data: 573977-51-2(Hazardous Substances Data)

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 40172-95-0 N-(furan-2-carbonyl)piperazine 

Relevant articles and documents

Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.

In continuing our search for selective alpha(1)-adrenoceptor (AR) antagonists, we have synthesized new alkoxyarylpiperazinylalkylpyridazinone derivatives. The new compounds were tested for their affinity toward alpha(1)- and alpha(2)-AR and toward the 5-HT(1A) receptor. alpha(1)-AR affinity data are in the subnanomolar range, with 3 showing an affinity of 0.052 nM, about 5-fold higher than prazosin. None of the studied compounds was found to be alpha(1)/alpha(2) selective, but 8 showed an interesting 5-HT(1A)/alpha(1) affinity ratio of 119.