57404-41-8Relevant academic research and scientific papers
Tetrahydrofolate coenzyme models: Imidazolines as nucleophilic C1-transfer reagents
Jones,Nichols
, p. 1767 - 1770 (1990)
1-Benzyl-2-imidazoline is deprotonated at C-2 and alkylated by a sulphenylation-substitution sequence (to complete a formal C1-transfer), whereas arylation occurs by an unusual sulphenylation-sulphide contraction pathway.
ALPHA HYDROXY AMIDES
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Page/Page column 37; 67; 68, (2014/04/17)
The present invention relates to alpha hydroxy amides including compounds of formula (I) and related compounds and their use in the prophylaxis and treatment of inflammatory disorders and diseases, wherein T1, T2, W and Rw has the meaning given in claim 1.
Coenzyme-inspired chemistry 1: The C-2 alkylation of 4,5-dihydroimidazoles
Jones, Raymond C.F.,Nichols, John R.
, p. 4114 - 4119 (2013/06/27)
Alkylation of 4,5-dihydroimidazoles at C-2 is accomplished using a double umpolung of the reactivity of that position, via sulfenylation of a nucleophilic C-2 lithio-species and substitution using an alkyl nucleophile. Arylation via unexpected sulfide con
