57404-85-0

Basic information

• Product Name: 1-Hydroxy-3-methoxynaphthalene
• Synonyms: 1-Hydroxy-3-methoxynaphthalene
• CAS NO: 57404-85-0
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.1959
• Mol File: 57404-85-0.mol

Chemical Properties

• Boiling Point: 348.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• PKA: 9.15±0.40(Predicted)
• CAS DataBase Reference: 1-Hydroxy-3-methoxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxy-3-methoxynaphthalene(57404-85-0)
• EPA Substance Registry System: 1-Hydroxy-3-methoxynaphthalene(57404-85-0)

Safety Data

• Hazardous Substances Data: 57404-85-0(Hazardous Substances Data)

Usage

Appearance

White to off-white crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Usage

Fluorescent dye for coloring materials (plastics, fibers, rubbers), intermediate for synthesis of pharmaceuticals and agrochemicals

Properties

Anti-inflammatory and antioxidant

Potential applications

Medicinal and cosmetic products

Safety precautions

Potential hazards include skin and eye irritation; proper handling and storage are important

Upstream product

• 132-86-5 1,3-dihydroxynaphthalene 
• 93-04-9 2-Methoxynaphthalene 
• 67-56-1 methanol 

Downstream Products

• 1011288-38-2 3-[4-(hexyloxy)phenyl]-3-[4-(4-methylpiperidino)phenyl]-6-(4'-hydroxy-4-biphenyl)-3H-naphtho[2,1-b]pyran 
• 1011288-03-1 4-(4'-hydroxy-4-biphenyl)-2-naphthol 
• 1011288-02-0 3-methoxy-1-(4'-methoxy-4-biphenyl)naphthalene 
• 181280-87-5 Toluene-4-sulfonic acid 3-[(di-tert-butoxy-phosphoryl)-difluoro-methyl]-naphthalen-1-yl ester 
• 181280-85-3 Toluene-4-sulfonic acid 3-[(di-tert-butoxy-phosphoryl)-hydroxy-methyl]-naphthalen-1-yl ester 
• 181280-86-4 Toluene-4-sulfonic acid 3-(di-tert-butoxy-phosphoranecarbonyl)-naphthalen-1-yl ester 
• 181280-79-5 [3-(trifluoromethylsulfonyloxy)-1-naphthyl] 4-methylbenzenesulfonate 
• 181280-80-8 4-(Toluene-4-sulfonyloxy)-naphthalene-2-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 181280-82-0 4-(Toluene-4-sulfonyloxy)-naphthalene-2-carboxylic acid methyl ester 
• 181280-81-9 4-(Toluene-4-sulfonyloxy)-naphthalene-2-carboxylic acid 
• 181280-83-1 Toluene-4-sulfonic acid 3-hydroxymethyl-naphthalen-1-yl ester 

Relevant articles and documents

RAS INHIBITORS AND METHODS OF USING THE SAME

Provided herein are compounds identified as inhibitors of KRAS protein activity that can be used to treat various diseases and disorders, such as cancer.

INHIBITORS OF KRAS G12C PROTEIN AND USES THEREOF

Provided are novel compounds useful as inhibitors of the KRAS protein, as well as pharmaceutical compositions comprising these compounds and methods of treatment by administration of these compounds or the pharmaceutical compositions.

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Synthesis and Photochromism of Novel Pyridyl-Substituted Naphthopyrans

Multitarget synthetic strategies to access novel photochromic 3H-naphtho[2,1-b]pyrans decorated with pyridyl units are described. The new pyridyl-substituted 3H-naphtho[2,1-b]pyrans display good photochromic properties with reversible generation of photomerocyanines, which exhibit mainly orange/red hues. Photochromic parameters including photocolorability and persistence of color vary tremendously on structural modification of the naphthopyran core.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND

An organometallic compound represented by Formula 1: wherein, in Formula 1, groups and variables are the same as described in the specification.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents

Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Accessing Polyoxygenated Dibenzofurans via the Union of Phenols and o-Benzoquinones: Rapid Syntheses of Metabolites Isolated from Ribes takare

The construction of polyoxygenated dibenzo[b,d]furan frameworks from the union of substituted phenols/naphthols and o-benzoquinones via a Michael-oxidation-oxa-Michael cascade is reported. The power of this transformation is demonstrated in the generation of a library of highly substituted dibenzofurans, featuring specifically substituted molecules containing broad ranges of functionality. The utility of this method is showcased in the total syntheses of two dibenzofurans isolated from Ribes takare, assembling the carbon scaffold of both natural products in one operation.