57415-44-8Relevant academic research and scientific papers
Production method of flecainide
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Paragraph 0088-0089, (2020/05/01)
The invention belongs to the technical field of compound synthesis, and particularly relates to a production method of flecainide, which comprises the following steps: 1) etherification reaction, 2) acetylation reaction, 3) oxidation reaction and 4) refining. According to the production method, qualified flecainide is synthesized through three steps, the process steps are simplified, the process operation is simple, the etherification reaction, the acetylation reaction and the oxidation reaction are adopted, so that the flecainide yield is stable, the yield is high, the impurity separation iseasily achieved, and the impurity operation is simple and convenient.
Preparation of acid addition salts of amine bases by solid phase-gas phase reactions
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Page/Page column 3; 4, (2008/06/13)
A process for the preparation of an acid addition salt of an organic base comprising exposing the organic base in solid form to a gaseous acid, with the proviso that ziprasidone, its acid addition salts and intermediates thereof are excluded.
Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
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, (2008/06/13)
Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a substituted benzamido group, and their pharmaceutically acceptable salts, are found to be active as antiarrhythmic agents.
