57427-89-1

Basic information

• Product Name: 4-((E)-4-hydroxy-benzylidene)-2-phenyl-4H-oxazol-5-one
• Synonyms: 4-((E)-4-hydroxy-benzylidene)-2-phenyl-4H-oxazol-5-one
• CAS NO: 57427-89-1
• Molecular Weight: 265.268
• Mol File: 57427-89-1.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 4-((E)-4-hydroxy-benzylidene)-2-phenyl-4H-oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((E)-4-hydroxy-benzylidene)-2-phenyl-4H-oxazol-5-one(57427-89-1)
• EPA Substance Registry System: 4-((E)-4-hydroxy-benzylidene)-2-phenyl-4H-oxazol-5-one(57427-89-1)

Safety Data

• Hazardous Substances Data: 57427-89-1(Hazardous Substances Data)

Upstream product

• 32089-82-0 2-benzoylamino-3-(4-hydroxy-phenyl)-acrylic acid 
• 495-69-2 Hippuric Acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1199-01-5 2-phenylazlactone 
• 108-24-7 acetic anhydride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 32089-82-0 (E)-2-Benzoylamino-3-(4-hydroxy-phenyl)-acrylic acid 
• 136713-01-4 3-(1H-Benzoimidazol-2-ylamino)-5-[1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-3,5-dihydro-imidazol-4-one 
• 138973-08-7 1,4-Bis(5'-(4-hydroxybenzylidene)-2'-phenyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 140935-58-6 2-(Benzooxazol-2-ylsulfanyl)-N-{4-[1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 105625-57-8 3-Ethyl-5-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-2-phenyl-3,5-dihydro-imidazol-4-one 
• 140935-48-4 2-(Benzothiazol-2-ylsulfanyl)-N-{4-[1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-acetamide 
• 133357-47-8 2-(p-hydroxybenzyl)-2-benzamidoethylamine 
• 94460-79-4 N-[1-Hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-benzimidic acid 
• 97492-73-4 5-(4-hydroxy-benzylidene)-2-phenyl-3,5-dihydro-imidazol-4-one 
• 1252042-85-5 C₂₃H₁₃Cl₂N₃O₂S 
• 1422722-58-4 4-(4-hydroxybenzylidene)-1-(4-oxo-2-phenyl-4Hchromen-6-yl)-2-phenyl-1H-imidazol-5-one 
• 136712-94-2 3-(Benzothiazol-2-ylamino)-5-[1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-3,5-dihydro-imidazol-4-one 
• 136713-09-2 3-(Benzooxazol-2-ylamino)-5-[1-(4-hydroxy-phenyl)-meth-(Z)-ylidene]-2-phenyl-3,5-dihydro-imidazol-4-one 

Relevant articles and documents

An ionic liquid gel: A heterogeneous catalyst for Erlenmeyer-Plochl and Henry reactions

An ionic liquid gel has been prepared by entrapping 1-butyl-3-methylimidazolium hydroxide ([Bmim]OH) in an aqueous agar gel. The ionic liquid gel has been characterized by Fourier transform infrared (FT-IR), Fourier transform Raman (FT-Raman) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and energy dispersive X-ray analysis (EDX). The ionic liquid gel has been successfully employed as a heterogeneous catalyst in the Erlenmeyer-Plochl reaction involving aldehydes, hippuric acid and acetic anhydride as well as in the Henry reaction between aldehydes and nitromethane in ethanol at room temperature. The heterogeneity of the ionic liquid gel has been confirmed by conducting hot filtration tests and leaching studies. Additionally, the ionic liquid gel could be easily recovered by simple filtration and reused five times without significant loss in catalytic activity.

Benzothiazol clubbed imidazol-4-ones as anti-fungal, anti-tubercular and anti-HIV-1 agents: Their synthesis and molecular docking study

Background: The present work describes antimicrobial, antimycobacterium and anti HIV-1 evaluation of newly synthesized 5-(4-Substituted-benzylidene)-3-[4-(5-methyl-benzothiazol2-yl)-phenyl]-2-phenyl-3,5-dihydro-imidazol-4-one (4a-o). The docking studies were performed in order to predict the potential binding affinities. Objective: The major aim of this study is to develop the new class of bezylidine candidate clubbed with benzothiazole with less toxicity and improved potency as antimicrobial, antitubercular and anti HIV-1. Methods: The titled compounds were characterized by spectral studies (IR, 1H NMR, 13C NMR and Mass). In vitro antimycobacterium activity was carried out using Lowenstein-Jensen medium method and antimicrobial activity using the broth microdilution method. The anti HIV-1 reverse transcriptase activity was determined by the colorimetric MTT method and inhibition of virusinduced cytopathogenicity in MT-4 cells. Results: Compound 4i (50 μM) showed better antifungal activity against A. clavatus. Compound 4g (50 μM) with 95% inhibition demonstrated good activity against M. tuberculosis H37Rv. Compound 4k showed CC50 (50 μM) against MT-4 (CD4+ Human T-cells containing an integrated HTLV-1 genome) cells by 50%, while 16 μM concentration value EC50 from the HIV-1 induced cytopathogenicity. Molecular docking study suggested that 4k interacted with the target with binding energy by Vina score (-10.3 Kcal/mol) Conclusion: The preliminary in vitro evaluation results revealed that some of the compounds have promising antimicrobial activities as well as antitubercular potency. Among the various substituents on benzylidene, the nitro group was the most beneficial for improving the anti-HIV-1 activity. Docking result suggested that 4k compound could be acting as a non-competitive or weak inhibitor of Reverse Transcriptase (RT).

Silica-supported Solvent Approaches More Facile than the Conventional for Erlenmeyer Synthesis with Our Pyridinium Salts

The synthesis of pyridinium salts by both conventional/silica-supported muffle furnace and microwave approaches is described. We have optimized the Erlenmeyer synthesis of azalactone with various concentrations of our synthesized pyridinium salts. Among t