57427-99-3

Upstream product

• 495-69-2 Hippuric Acid 
• 66-77-3 1-naphthaldehyde 
• 703-55-9 1-naphthylmagnesiumbromide 
• 4780-79-4 1-naphthalene methanol 

Downstream Products

• 59759-78-3 2-benzoylamino-3-naphthalen-1-yl-propionic acid 
• 144754-21-2 2-benzoylamino-3-[1]naphthyl-acrylic acid 
• 708276-89-5 methyl (Z)-2-benzoylamino-3-(1-naphthyl)-2-propenoate 
• 708277-00-3 isopropyl (Z)-2-benzoylamino-3-(1-naphthyl)-2-propenoate 
• 708277-04-7 tert-butyl (Z)-2-benzoylamino-3-(1-naphthyl)-2-propenoate 
• 95953-52-9 4-(naphthalen-1-yl-phenyl-methyl)-2-phenyl-4H-oxazol-5-one 
• 1643501-21-6 (Z)-N-(1-bromo-3-(diethylamino)-1-(naphthalen-1-yl)-3-oxoprop-1-en-2-yl)benzamide 
• 1643501-50-1 N,N-diethyl-5-(naphthalen-1-yl)-2-phenyloxazole-4-carboxamide 
• 160383-65-3 [α-benzamido-α-(naphthylmethylidene) methyl]3-hydroxy-4H-3,1-quinazolin-4-one 
• 957323-40-9 [α-benzamido-α-(2-naphthylmethylidene)methyl]3-amino-4-H-3,1-quinazolin-4-one 
• 145326-68-7 2-(α-benzoylamino-β-2-naphthylacrylamido)-4H-3,1-benzoxazin-4-one 

Relevant academic research and scientific papers

Novel and chemoselective one-pot synthesis of 4-arylidene-2-phenyl-5(4H)- oxazolones starting from benzyl alcohols promoted by [(C14H 24N4)2W10O32]-[bmim] NO3

A new and practical promoter system for one-pot, efficient, chemoselective synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones using [(C14H 24N4)2W10O32]-[bmim] NO3 under solvent-free conditions is described. The present work opens up a new and ecofriendly synthetic route to Erlenmeyer-Ploechl adducts from primary benzyl alcohols in a one-pot operation. Graphical abstract: [Figure not available: see fulltext.]

Dynamic Kinetic Resolution of Azlactones by a Chiral N, N-Dimethyl-4-aminopyridine Derivative Containing a 1,1′-Binaphthyl Unit: Importance of Amide Groups

A dynamic kinetic resolution (DKR) of azlactones in the presence of benzoic acid and a binaphthyl-based N,N-4-dimethylaminopyridine (DMAP) derivative 1i having two amide groups at the 3,3′-positions of a binaphthyl unit is developed. The reaction proceeded smoothly with a wide range of azlactones to provide α-amino acid derivatives with good to high enantiomeric ratios (er's). A multigram-scale reaction (2.5 g) for the DKR of azlactone 2d was also demonstrated, and the resulting product was converted to unnatural α-amino acid 6d′.

An innovation for development of Erlenmeyer-Pl?chl reaction and synthesis of AT-130 analogous: A new application of continuous-flow method

The development of eco-friendly and efficient processes via one-pot multicomponent synthesis is a very attractive topic. In this work, the Erlenmeyer-Pl?chl azlactone synthesis was carried out through unique, safe, fast and practical conditions without any catalyst, applying a simple microreactor and gave the corresponding products exclusively. A continuous, first microflow synthesis of N-benzoylglycine carbamide derivatives as AT-130 analogues catalyzed by Nafion-H@SPIONs was also established successfully.

A concise approach to polysubstituted oxazoles from N-acyl-2-bromo enamides via a copper(i)/amino acid-catalyzed intramolecular C-O bond formation

A straightforward and efficient copper(i)/amino acid-catalyzed intramolecular Ullmann-type C-O coupling reaction has been developed. This protocol affords a facile methodology for the synthesis of a series of novel 2,4,5-substituted oxazoles from readily accessible N-acyl-2-bromo enamides under mild conditions. This journal is the Partner Organisations 2014.

Sulfur-and n-acyl carbonyl oxygen-assisted heterolysis of the C(=O)-S bond in excited-state (Z)-nacyl-α-dehydro(1-naphthyl)alanine thioesters

Irradiation of the title thioesters (Z)-1 in nitrogen-saturated 1,2- dichloroethane at wavelengths greater than 280 nm was found to afford (Z)-4-(1- naphthylmethylene)-5(4H)-oxazolone derivatives (Z)-2, (E)-2, alkyl-substituted thiols 3, and (E)-1 without

Synthesis of some heterocyclic molecuoles from new benzoxazinones and quinazolinones

THE BENZOXAXAZINONE 3 was prepared and treated with hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine to give different quinazolinones 4,5 and benzoimidazoles 6, 7, respectively.Product 4 reacted with different aldehydes forming diffe

2W10O32. 2H2O: A novel and powerful catalyst for the synthesis of 4-arylidene-2-phenyl-5(4)-oxazolones under ultrasonic condition

Di[1,6-bis(3-methylimidazolium-1-yl)hexane] decatungstate dihydrate ([C6(MIm)2]2W10O32. 2H2O) as a new family of polyoxometalate-based dicationic ionic liquids (POM-DIL) is synthesized and employed as a novel and powerful heterogeneous catalyst in the synthesis of 4-arylidene-2-phenyl-5(4)-oxazolones (azlactones) under ultrasound-assisted solvent-free condition. On the basis of the results, the products were obtained in excellent yields under mild condition. Utilization of easy work-up and purification make it very interesting from an economic perspective. Moreover, a recycling study confirmed that the catalyst can be reused multiple times without significant loss of its activity.

NEW COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYES AND PIGMENTS

Compounds of formula (1) wherein R1 is hydrogen, hydroxy, halogen, nitro, cyano, amino, carboxy, carboxylic ester, sulfo, sulfonic ester, carboxylic amide, sulfonic amide, alkoxy, aryloxy, alkylthio or arylthio, X is -0-, -S-, -NH- or -N(alkyl)-, Y is hyd

Oxazolone analogs as amyloid aggregation inhibitors and for the treatment of alzheimer's disease and disorders related to amyloidosis

Disclosed are compounds of the Formula I and their use in a method of inhibiting the aggregation of amyloid proteins and in a method of imaging amyloid deposits.

Ring opening with kinetic resolution of azlactones by Ti-TADDOLates

The kinetic resolution of azlactones by the Lewis, acid-mediated transfer of an isopropoxide ligand from the chiral ligand sphere of Ti- TADDOLate is described. The reactions proceed with in-situ racemization of the starting material to afford highly enantiomerically enriched N-benzoyl- amino acid isopropylesters (er > 95:5 after recrystallization). The absolute configuration of the major enantiomer of N-benzoyl-phenylalanine isopropyl ester and its analogs with other aromatic substituents was shown to be (S)- (+) when the (R,R)-Ti-TADDOLate was employed. Only benzyl-substituted azlactones can be opened enantioselectively by the method described here.