57438-18-3Relevant academic research and scientific papers
Preparation and application of antibody for bispecific recognition of albendazole and carbendazim
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Paragraph 0071-0074, (2021/08/28)
The invention discloses preparation and application of an antibody for bispecific recognition of albendazole and carbendazim. Hapten is coupled to carrier protein to prepare two artificial antigens, the two artificial antigens are respectively used for animal immunization and used as coating antigen, hybridoma cells capable of secreting albendazole and/or carbendazim antibodies are prepared through cell fusion, and further a detection method based on indirect competitive enzyme-linked immunosorbent assay is established by using the coating antigen. The detection method for detecting albendazole and/or carbendazim has the characteristics of strong specificity, high sensitivity, rapidness, simplicity, convenience and the like, wherein the IC50 value of albendazole is 0.04 ng/mL, and the linear range is 0.02-0.09 ng/mL; and the IC50 value of the carbendazim is 3.35 ng/mL, and the linear range of the carbendazim is 0.95 -11.77 ng/mL. The detection method can be used for detecting albendazole in animal food and can also be used for detecting carbendazim in vegetables, so that multiple purposes are realized.
Synthesis and biological activity of certain alkyl 5(alkoxycarbonyl)-1H- benzimidazole-2-carbamates and related derivatives: A new class of potential antineoplastic and antifilarial agents
Ram,Wise,Wotring,McCall,Townsend
, p. 539 - 547 (2007/10/02)
A series of methyl and ethyl 5-(alkoxycarbonyl)-1H-benzimidazole-2- carbamates (7-19) and methyl 5-carbamoyl-1H-benzimidazole-2-carbamates (24- 34) have been synthesized via the reaction of an appropriate alcohol or amine with the acid chloride derivative
