57441-32-4

Upstream product

• 17498-71-4 3-methyl-2-phenyl-1-butene 
• 57441-31-3 2-(3-Methyl-2-phenyl-but-2-enyl)-malonic acid 

Downstream Products

• 869811-12-1 methyl 5-methyl-4-phenylhex-4-enoate 
• 57441-43-7 5-Methyl-4-phenyl-hex-4-enoyl chloride 
• 57441-33-5 1-Diazo-6-methyl-5-phenyl-hept-5-en-2-one 
• 51229-06-2 C₂₅H₂₄ 

Relevant academic research and scientific papers

Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates

Pd0-catalyzed Mizoroki–Heck reactions traditionally exhibit poor reactivity with polysubstituted, unbiased alkenes. Intermolecular reactions with simple, all-carbon tetrasubstituted alkenes are unprecedented. Herein we report that pendant carboxylic acids, combined with bulky monophospine ligands on palladium, can direct the arylation of tri- and tetrasubstituted olefins. Quaternary carbons are established at high Fsp3 attached-ring junctures and the carboxylate directing group can be removed after coupling. Carboxylate directivity prevents over-arylation of the new, less substituted alkene, which can be diversified in subsequent reactions.