5746-37-2Relevant academic research and scientific papers
Investigating the microwave-accelerated Claisen rearrangement of allyl aryl ethers: Scope of the catalysts, solvents, temperatures, and substrates
Hui, Zi,Jiang, Songwei,Qi, Xiang,Ye, Xiang-Yang,Xie, Tian
supporting information, (2020/05/18)
The microwave-accelerated Claisen rearrangement of allyl aryl ethers was investigated, in order to gain insight into the scope of the catalysts, solvents, temperatures, and substrates. Among the catalysts examined, phosphomolybdic acid (PMA) was found to greatly accelerate the reaction in NMP, at temperatures ranging from 220 to 300 °C. This method was found to be useful for preparing several intermediates previously reported in the literature using precious metal catalysts such as Au(I), Ag(I), and Pt(II). Additionally, substrates bearing bromo and nitro groups on the aryl portion required careful tailoring of the reaction conditions to avoid complex product profiles.
Synthesis of 3-Methylobovatol
Pilkington, Lisa I.,Barker, David
, p. 2425 - 2428 (2015/10/19)
Biphenyl lignans are rare compounds that exhibit a broad range of biological activities. The first total synthesis of natural biphenyl ether lignan, 3-methylobovatol, has been achieved in four steps. This synthesis allows for modification of the C-2 phenol and in doing so, will facilitate various structure-activity relationship studies into these bioactive compounds.
A practical highly selective oxybromination of phenols with dioxygen
Menini, Luciano,Parreira, Luciana A.,Gusevskaya, Elena V.
, p. 6401 - 6404 (2008/02/12)
A simple, low cost and highly selective method for the synthesis of mono-bromophenols from phenol and electron-rich phenolic compounds has been developed. Bromide ions are used as halogenating agents, dioxygen as a final oxidant, and Cu(OAc)2 as a catalyst.
4,4-Dibromo-3-methylpyrazol-5-one: New applications for selective monobromination of phenols and oxidation of sulfides to sulfoxides
Mashraqui, Sabir H.,Mudaliar, Chandrashekar D.,Hariharasubrahmanian, Harini
, p. 4865 - 4868 (2007/10/03)
Dibromopyrazolone 1, a stable, crystalline solid effects para selective monobromination of phenols and aniline substrates under mild conditions. Selective oxidation of sulfides to sulfoxides can also be accomplished by using 1 in high yields.
