33441-56-4

Basic information

• Product Name: ETHYL O-THIOSALICYLATE
• Synonyms: ETHYL O-THIOSALICYLATE;Ethyl 2-mercapto benzoate;Benzoic acid, 2-Mercapto-, ethyl ester
• CAS NO: 33441-56-4
• Molecular Formula: C₉H₁₀O₂S
• Molecular Weight: 182.2395
• Mol File: 33441-56-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 277.6±23.0 °C(Predicted)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• PKA: 5.88±0.43(Predicted)
• CAS DataBase Reference: ETHYL O-THIOSALICYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL O-THIOSALICYLATE(33441-56-4)
• EPA Substance Registry System: ETHYL O-THIOSALICYLATE(33441-56-4)

Safety Data

• Hazardous Substances Data: 33441-56-4(Hazardous Substances Data)

Upstream product

• 54481-26-4 bis(2-ethoxycarbonylphenyl) disulfide 
• 64-17-5 ethanol 
• 147-93-3 Thiosalicylic acid 
• 658702-69-3 N-[(2-ethoxycarbonylbenzene)sulfenyl]benzimidazole 
• 6258-66-8 (4-chlorophenyl)methanethiol 

Downstream Products

• 121355-96-2 (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-{[2-(ethoxycarbonyl)phenyl]thio}tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 86231-04-1 1-methyl-4-nitro-5-(2-carbethoxyphenyl)mercaptoimidazole 
• 3354-42-5 3H-1,2-benzodithiole-3-thione 
• 72368-60-6 diethyl-4-methoxyphenylphosphonotrithioate 
• 80283-38-1 2-(p-methoxyphenyl)-4H-1,3,2-benzodithiaphosphorin-4-one 2-sulfide 
• 134330-66-8 Ethyl S-(3-cyanopropyl)thiosalicylate 
• 104864-52-0 2-(1-Carbamoyl-ethylsulfanyl)-benzoic acid ethyl ester 
• 147067-17-2 2-(6-Methyl-1,4,8,11-tetraoxa-cyclotetradec-6-ylmethylsulfanyl)-benzoic acid ethyl ester 
• 115261-61-5 diethyl 2,2'-methylenebis(thio)bisbenzoate 
• 22786-76-1 ethyl 2-acethylthiobenzoate 
• 140425-59-8 ethyl 2-(2'-nitrophenylthio)benzoate 
• 1527-13-5 2-Phenylthiobenzoesaeureethylester 
• 1426657-39-7 ethyl 2-(((2S,3S,4S)-2-((ethoxycarbonyl)methyl)-3-methyl-3-nitro-chroman-4-yl)sulfanyl)benzoate 
• 41907-48-6 ethyl 3-(2-ethoxycarbonylphenylthio)propionate 

Relevant articles and documents

Synthesis and biological evaluation of sulfur-containing cinnamate and salicylate derivatives

UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2,2′-dithiocinnamate derivatives and 2,2′-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological activities of the synthesized compounds were assayed for ABTS [2,2′-azinobis-(3-ethyl-benzo- thiazoline-6-sulfonic acid)] radical scavenging activity, MMP-1 inhibitory activity, and cytotoxicity to human dermal fibroblast cells. Compounds with potential of resistance to UV irradiation were identified. These compounds are expected to be useful for preventing photo-damage to the skin.

New macrocyclic ligands. XIV: Synthesis and X-ray structures of potentially pentadentate ligands incorporating non-symmetrically arranged N4S-, N3OS-, N2O2S- and N2S2O-heteroatoms

The synthesis and characterization of new mixed-donor macrocyclic ligands incorporating nitrogen, sulfur and/or oxygen heteroatoms are described. The new 17- or 18-membered macrocyclic rings contain unsymmetrical arrangements of their heteroatoms in contr

No-donors, part 3: Nitrooxyacylated thiosalicylates and salicylates - Synthesis and biological activities

Organic nitrates release nitric oxide when incubated with thiosalicylic acid. S-Nitrooxyacylated esters and amides of thiosalicylic acid, together with the corresponding salicylates, were synthesized in order to perform a first in vitro evaluation of these new nitrate-thiol-hybrid prodrugs. These prodrugs might release NO in vivo after biotransformation without the use of endogenous reductives. None of these prodrugs released NO spontaneously when dissolved in buffer solution, but they did activate soluble guanylyl cyclase and induced vasodilatation of phenylephrine-pretreated male Wistar rat aorta in a potency range between that of isosorbiddinitrate and glycerole trinitrate.