33441-56-4

Upstream product

• 64-17-5 ethanol 
• 147-93-3 Thiosalicylic acid 
• 658702-69-3 N-[(2-ethoxycarbonylbenzene)sulfenyl]benzimidazole 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 54481-26-4 bis(2-ethoxycarbonylphenyl) disulfide 

Downstream Products

• 3354-42-5 3H-1,2-benzodithiole-3-thione 
• 72368-60-6 diethyl-4-methoxyphenylphosphonotrithioate 
• 80283-38-1 2-(p-methoxyphenyl)-4H-1,3,2-benzodithiaphosphorin-4-one 2-sulfide 
• 134330-66-8 Ethyl S-(3-cyanopropyl)thiosalicylate 
• 104864-52-0 2-(1-Carbamoyl-ethylsulfanyl)-benzoic acid ethyl ester 
• 147067-17-2 2-(6-Methyl-1,4,8,11-tetraoxa-cyclotetradec-6-ylmethylsulfanyl)-benzoic acid ethyl ester 
• 115261-61-5 diethyl 2,2'-methylenebis(thio)bisbenzoate 
• 860778-56-9 ethyl 2-(4'-methyl-2'-nitrophenylthio)benzoate 
• 851974-53-3 ethyl 2-(4'-ethenyl-2'-nitrophenylthio)benzoate 
• 507259-77-0 2-[2-(2-formyl-phenoxy)-ethylsulfanyl]-benzoic acid ethyl ester 
• 507259-81-6 C₁₉H₂₁NO₄S 
• 483341-34-0 1-[3-(2-ethoxycarbonyl-phenylsulfanyl)-2-hydroxy-propyl]-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1426657-39-7 ethyl 2-(((2S,3S,4S)-2-((ethoxycarbonyl)methyl)-3-methyl-3-nitro-chroman-4-yl)sulfanyl)benzoate 
• 1527-13-5 2-Phenylthiobenzoesaeureethylester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of sulfur-containing cinnamate and salicylate derivatives

UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2,2′-dithiocinnamate derivatives and 2,2′-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological activities of the synthesized compounds were assayed for ABTS [2,2′-azinobis-(3-ethyl-benzo- thiazoline-6-sulfonic acid)] radical scavenging activity, MMP-1 inhibitory activity, and cytotoxicity to human dermal fibroblast cells. Compounds with potential of resistance to UV irradiation were identified. These compounds are expected to be useful for preventing photo-damage to the skin.

N-(2-Alkoxycarbonylbenzenesulfeny)benzimidazoles as nitrogen-, sulfur-, and carbon-sulfenylation reagents

N-(2-Alkoxycarbonylbenzenesulfenyl)benzimidazoles reacted with nucleophiles such as amides, imidates, thiols, Grignard reagents, and active methylene compounds to yield the corresponding sulfenylated products: N-acylsulfenamides, N-sulfenylimidates, disulfides, sulfides, and sulfenylated active methylene compounds, respectively.

New macrocyclic ligands. XIV: Synthesis and X-ray structures of potentially pentadentate ligands incorporating non-symmetrically arranged N4S-, N3OS-, N2O2S- and N2S2O-heteroatoms

The synthesis and characterization of new mixed-donor macrocyclic ligands incorporating nitrogen, sulfur and/or oxygen heteroatoms are described. The new 17- or 18-membered macrocyclic rings contain unsymmetrical arrangements of their heteroatoms in contr

Biological activity of alkyl 2-(acylthio)benzoates

Of a series of synthetic alkyl 2-(acylthio)benzoate (1-20), all the derivatives except for n-butyl 2-butyrylthiobenzoate (18) and n-butyl 2-n- valerylthiobenzoate (20) showed clear phytogrowth-inhibitory activity. All the compounds tested except for methyl 2-butyrylthiobenzoate (3) exhibited cytotoxic activity on mouse splenic T cells. Strong phytogrowth-inhibition and cytotoxic activity were found with 1, 6, 11 and 16 with an acetylthio group at C-2, suggesting that the acetyl group seems to play an important role in both activities of alkyl 2(acylthio)benzoates. Among them, methyl 2- acetylthiobenzoate (1) was the strongest inhibitor. On the other hand, potent inhibition of prolyl endopeptidase was exhibited by 2, 7, 12 and 17 with a propionylthio group at C-2. These findings imply that a propionyl group might be useful for increasing the inhibitory activity against on prolyl endopeptidase.

No-donors, part 3: Nitrooxyacylated thiosalicylates and salicylates - Synthesis and biological activities

Organic nitrates release nitric oxide when incubated with thiosalicylic acid. S-Nitrooxyacylated esters and amides of thiosalicylic acid, together with the corresponding salicylates, were synthesized in order to perform a first in vitro evaluation of these new nitrate-thiol-hybrid prodrugs. These prodrugs might release NO in vivo after biotransformation without the use of endogenous reductives. None of these prodrugs released NO spontaneously when dissolved in buffer solution, but they did activate soluble guanylyl cyclase and induced vasodilatation of phenylephrine-pretreated male Wistar rat aorta in a potency range between that of isosorbiddinitrate and glycerole trinitrate.

Benzothiazinone derivatives

The invention provides benzothiazinone derivatives of formula STR1 wherein R1 represents a nitrogen-containing heteroaromatic group or a phenyl group substituted by 1 or 2 substituents selected from halogen atoms, alkyl, haloalkyl and alkoxy gr

New Macrocyclic Ligands. Synthesis of an Extensive Series of Potentially Pentadentate Ligands Containing Mixed Nitrogen, Oxygen and/or Sulfur Heteroatoms. The X-Ray Structure of an O2N2S Derivative

The syntheses of 16 new 16- to 19-membered dibenzo macrocycles are reported.These rings incorporate nitrogen together with oxygen and/or sulfur heteroatoms.The X-ray structure of the 17-membered macrocycle containing an O2N2S heteroatom set is described.