57479-23-9Relevant academic research and scientific papers
Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines
Hassan, Mirja Md Mahamudul,Hoque, Md Emdadul,Dey, Sayan,Guria, Saikat,Roy, Brindaban,Chattopadhyay, Buddhadeb
supporting information, p. 3333 - 3342 (2021/06/18)
We report a convenient method for the highly site-selective borylation of 8-arylquinoline. The reaction proceeds smoothly in the presence of a catalytic amount of [Ir(OMe)(cod)] 2and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The reactions occur with high selectivity with many functional groups, providing a series of borylated 8-aryl quinolines with good to excellent yield and excellent selectivity. The borylated compounds formed in this method can be transformed into various important synthons by using known transformations.
Ru-Catalyzed Deoxygenative Regioselective C8-H Arylation of Quinoline N-Oxides
Kim, Jinwoo,Kim, Suhyeon,Kim, Dongwook,Chang, Sukbok
, p. 13150 - 13158 (2019/08/22)
Regioselective C-H functionalization on quinolines is of high interest to lead to value-added products. Herein, we describe the development of Ru-catalyzed deoxygenative regioselective C8 arylation of quinoline N-oxides with arylboronic esters. Mechanistic studies revealed that it proceeds in a tandem process of arylation and then deoxygenation, wherein both steps were found to be catalytic with the ruthenium species.
