57479-60-4

Basic information

• Product Name: 2-(2-chlorophenyl)-1-phenylethan-1-one
• Synonyms: 2-(2-chlorophenyl)-1-phenylethan-1-one;2-(2-Chlorophenyl)-1-phenylethanone;Einecs 260-760-6
• CAS NO: 57479-60-4
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.68954
• EINECS: 260-760-6
• Mol File: 57479-60-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 350.6°Cat760mmHg
• Flash Point: 192.2°C
• Appearance: /
• Density: 1.191g/cm³
• Vapor Pressure: 4.34E-05mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-(2-chlorophenyl)-1-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenyl)-1-phenylethan-1-one(57479-60-4)
• EPA Substance Registry System: 2-(2-chlorophenyl)-1-phenylethan-1-one(57479-60-4)

Safety Data

• Hazardous Substances Data: 57479-60-4(Hazardous Substances Data)

Usage

General Description

2-(2-chlorophenyl)-1-phenylethan-1-one, also known as Fluorolone, is an organic compound with the molecular formula C14H11ClO. It is a pale yellow solid that is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is a ketone, which means it contains a carbonyl group attached to two hydrocarbon groups. It is also classified as an aryl ketone, as it contains an aryl group (phenyl) bonded to the carbonyl group. 2-(2-chlorophenyl)-1-phenylethan-1-one is a key building block in the production of various pharmaceuticals and is commonly used in the synthesis of anti-inflammatory drugs and other therapeutic agents.

InChI:InChI=1/C14H11ClO/c15-13-9-5-4-8-12(13)10-14(16)11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 71-43-2 benzene 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 100-47-0 benzonitrile 
• 603-33-8 triphenylbismuthane 
• 134-81-6 benzil 
• 95-49-8 2-methylchlorobenzene 
• 611-73-4 Benzoylformic acid 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 591-51-5 phenyllithium 
• 93-58-3 benzoic acid methyl ester 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 5033-73-8 2-(2-chlorophenyl)-2-hydroxy-1-phenylethan-1-one 
• 5033-68-1 2-bromo-2-(2-chloro-phenyl)-1-phenyl-ethanone 
• 1566598-75-1 ethyl 4-(2-chlorophenyl)-1,5-diphenyl-1H-pyrazole-3-carboxylate 
• 1566598-90-0 ethyl 4-(2-chlorophenyl)-1-(2,4-dichlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylate 
• 10604-22-5 3-phenylcinnoline 

Relevant articles and documents

Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple methyl benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alcohol products. This finding greatly increases the practicality and impact of this chemistry. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.

The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters

Commercially available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable.

Copper-Catalyzed Three-Component Carboboronation of Allenes Using Highly Strained Cyclic Ketimines as Electrophiles

A diastereoselective copper and NHC-ligand-catalyzed three-component difunctionalization of allenes with bis(pinacolato)diboron and 2H-azirines to afford borylated allylaziridines is described. The reaction exhibits complete diastereoselectivity and good yields, and the further chlorination of the corresponding borylated products was also performed. It is believed that the high ring-strain force of 2H-azirines facilitates the reaction. More chemical transformations of borylated allylaziridines are also reported.