57489-51-7

Upstream product

• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 1337935-93-9 C₁₉H₁₉N₃O₄ 
• 1337935-94-0 C₂₁H₂₂N₂O₃ 
• 1337935-95-1 C₂₁H₂₄N₂O₂ 
• 1337935-96-2 C₂₁H₂₁NO₃ 
• 1337935-97-3 C₁₉H₁₈ClNO₂ 
• 1337935-98-4 C₁₉H₁₈FNO₂ 
• 1337935-99-5 C₂₀H₁₈N₂O₂ 
• 1337935-90-6 C₁₉H₁₉NO₂ 
• 1337935-91-7 C₂₀H₁₈N₂O₂ 
• 1337935-92-8 C₁₉H₁₈N₂O₄ 
• 333303-27-8 2-acetoxy-5-bromo-4-(diethylamino)benzaldehyde 

Relevant academic research and scientific papers

Rational Design of a Red-Emissive Fluorophore with AIE and ESIPT Characteristics and Its Application in Light-Up Sensing of Esterase

The development of red fluorophores with efficient solid-state emission is still challenging. Herein, a red fluorophore 1 with aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics is rationally design

Development of 6-arylcoumarins as nonsteroidal progesterone antagonists. Structure–activity relationships and fluorescence properties

Progesterone is involved in multiple physiological processes, including female reproduction, via binding to the progesterone receptor (PR). We have developed 6-arylcoumarins such as 5 and 6 as non-steroidal PR antagonists with receptor-binding-dependent f

INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE

The invention is directed to inhibitors of cystathionine beta synthase which, among other biochemical effects, allow reduction of the neurotoxic overproduction of endogenous hydrogen sulphide. These compounds and pharmaceutical compositions containing them are useful for the prevention and treatment of cognitive disorders such as cognitive disorders in Down syndrome. The invention also relates to methods for preventing or treating cognitive disorders including cognitive disorders in Down Syndrome.

6-arylcoumarins as novel nonsteroidal type progesterone antagonists: An example with receptor-binding-dependent fluorescence

Various 6-arylcoumarin derivatives were designed and synthesized as candidate nonsteroidal type progesterone antagonists. 6-Bromocoumarin derivatives were prepared from the corresponding 4-substituted 2-acetoxy-5-bromobenzaldehyde by employing the Still-Gennari modification of the Horner-Wadsworth-Emmons olefination reaction and were converted to 6-arylcoumarins by means of Suzuki-Miyaura cross-coupling reactions. The biological activities of these coumarin derivatives were evaluated by means of alkaline phosphatase assay in the T47D human breast carcinoma cell line. Among the synthesized compounds, 36 (IC50 = 0.12 μM) and 38 (IC 50 = 0.065 μM), bearing a five-membered heterocycle, showed potent PR antagonist activity. Competitive binding assay showed that compounds 8 and 34 have potent PR binding affinity. The fluorescence of compound 8 was dependent on the solvent properties and was increased in the presence of PR ligand binding domain. This property might be applicable to the development of fluorescence probes for studies on PR.

Synthesis and fluorescence properties of substituted 7-aminocoumarin-3-carboxylate derivatives

4-Trifluoromethyl- or 6-bromo-substituted 7-diethylaminocoumarin-3-carboxamide derivatives 2 and 3, each containing a maleimide have been synthesized as potential fluorescent labeling reagents for thiol groups in proteins and their fluorescence properties have been determined. The 4-trifluoromethyl substituted compound 2 has a significantly greater Stokes shift than the comparable compound lacking this group, but both the new coumarins have low fluorescence quantum yields (φf). When a 4-trifluoromethyl substituent is present, the 3-carboxamide is unusually labile to hydrolysis. Bromination of ethyl 7-diethylaminocoumarin-3-carboxylate 17 gave the 6- and 8-bromo derivatives 18 and 19 respectively, and also the 8-bromo-7-monoethylamino compound 20. φf for the latter compound is 100-fold greater than for its diethylamino analogue 19. Fluorescence lifetime measurements support an interpretation based on the twisted intramolecular charge transfer (TICT) model to explain these large differences in φf.