57503-00-1

Upstream product

• 54043-60-6 1,3,5-tris(o-tolyl)-hexahydro-s-triazine 
• 13213-95-1 1-methyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one 
• 24827-66-5 1-methyl-1,3-dihydrobenzo[c]isothiazole-2,2-dioxide 
• 50-00-0 formaldehyd 
• 95-53-4 o-toluidine 

Downstream Products

• 1601483-90-2 (E)-methyl 2-(1,3-di-o-tolylimidazolidin-4-ylidene)acetate 
• 611-21-2 N,2-dimethylaniline 

Relevant academic research and scientific papers

Iron-Catalyzed Regioselective α-C-H Alkylation of N-Methylanilines: Cross-Dehydrogenative Coupling between Unactivated C(sp3)-H and C(sp3)-H Bonds via a Radical Process

The iron-catalyzed α-C-H alkylation of N-methylanilines without any directing group by cross-dehydrogenative coupling between unactivated C(sp3)-H and C(sp3)-H bonds has been established for the first time, which provides a good complement to C(sp3)-H activation reactions and expands the field of Fe-catalyzed C-H functionalizations. Many different C(sp3)-H bonds in cyclic alkanes, cyclic ethers, and toluene derivatives can be used as coupling partners. Mechanistic investigations including the radical reaction process, the main role of various reagents, and the kinetic isotope effect experiment were also described.

Expedient stereospecific Co-catalyzed tandem C-N and C-O bond formation of: N -methylanilines with styrene oxides

Cobalt(ii)-catalyzed stereospecific coupling of N-methylanilines with styrene oxides is developed via tandem C-N and C-O bond formation using tert-butyl hydroperoxide (TBHP) as an oxidant. Optically active epoxide can be reacted with high optical purity.

Mn(III)-based oxidative cyclization of N-aryl-3-oxobutanamides. facile synthesis and transformation of substituted oxindoles

The oxidation of 3-oxo-N-phenylbutanamides 1 with manganese(III) acetate in ethanol afforded dimeric 3,3'-biindoline-2,2'-dione derivatives 3-5. A similar reaction of N,2-disubstituted N-aryl-3-oxobutanamides 6 in acetic acid produced 3-acetylindolin-2-ones 7 bearing various substituents in good to excellent yields. The acetylindolinones 7 were easily deacetylated by treatment using neutral alumina in diethyl ether. Both the acetylindolinones 7 and deacetylated indolinones 8 were transformed by reduction into the substituted 1H-indoles.

Application of photoelectron spectroscopy to molecular properties, 57[≠] UV photoelectron spectroscopy studies of the products of thermal extrusion of sulfur dioxide from benzosultams

An aza-ortho-xylylene system is produced by thermal degradation of N- alkylbenzosultam, which can be directly studied by coupling the system to a UV/photoelectron spectrometer. These thermodynamically unstable xylylene derivatives rearrange to give aldimine by a [1,5] hydrogen shift.

Revisitation of Formaldehyde Aniline Condensation. VII. 1,3,5-Triarylhexahydro-sym-triazines and 1,3,5,7-Tetraaryl-1,3,5,7-tetrazocines from Aromatic Amines and Paraformaldehyde

A product study of the reaction between a number of aromatic amines substituted with widely different groups and paraformaldehyde in inert solvents was performed and found to yield 1,3,5-triaryl-1,3,5-hexahydrotriazines, 1,3,5,7-tetraaryl-1,3,5,7-tetrazocines and formaminals.It was not possible to correlate the product outcomes with the actual structure of the amine substrate.The X-ray diffraction structural determination of 1,3,5-tri-(t-butylphenyl)- (1b) and 1,3,5-tri-(m-fluorophenyl)-1,3,5-hexahydrotriazine (1c) showed the diaxial arrangement of the N-substituents.

GENERATION AND REACTIONS OF AZAXYLYLENES

Azaxylenes produced by flash vacuum pyrolysis of 2-aminobenzylalcohols, dihydrobenzoxazinones and dihydrobenzoxazines undergo intramolecular cyclisation, H-shifts or Diels-Alder reactions, depending on their substituents.