57519-88-7

Upstream product

• 1450-18-6 1,1,1-trimethyl-2,2,2-triphenyldisilane 
• 56-23-5 tetrachloromethane 
• 4235-65-8 tris(trimethylsilyl)phenylsilane 
• 98-13-5 Phenyltrichlorosilane 
• 76-86-8 Triphenylsilyl chloride 

Downstream Products

• 40633-36-1 1,1-dimethoxy-1-phenyl-2,2,2-trimethyldisilane 
• 67262-98-0 3-(dimethyl(phenyl)silyl)cyclohexanone 
• 109023-10-1 3-(dimethyl(phenyl)silyl)cyclopentanone 
• 145431-94-3 1,1-diethoxy-1-phenyl-2,2,2-trimethyldisilane 
• 89882-20-2 (RR,SS)-3-methyl-4-dimethyl(phenyl)silyl-4-phenylbutan-2-one 
• 89882-20-2 (RS,SR)-3-methyl-4-dimethyl(phenyl)silyl-4-phenylbutan-2-one 
• 115826-98-7 (R)-4-methyl-1-phenyl-3-(phenyldimethylsilyl)-1-pentanone 
• 115826-97-6 (R)-1-(4-methoxyphenyl)-3-(phenyldimethylsilyl)-1-butanone 
• 122438-97-5 syn-3-benzyl-1-phenyl-3-(phenyldimethylsilyl)-1-butanone 
• 122438-97-5 anti-3-benzyl-1-phenyl-3-(phenyldimethylsilyl)-1-butanone 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of β-hydroxy ketones by palladium-catalyzed asymmetric 1,4-disilylation of α,β-unsaturated ketones

1,4-Disilylation of β,β-unsaturated ketones with 1,1-dichloro-1-phenyl-2,2,2-trimethyldisilane proceeded in the presence of phosphine-palladium catalysts in benzene. High enantio-selectivity (up to 92%) was observed in the disilylation with dichloro[(R)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl] palladium(II) as a catalyst (0.5 mol %). The disilylation products, 1-(trimethyisilyloxy)-3-(dichlorophenylsilyl)propenes, were readily converted into optically active α-unsubstituted or anti α-substituted β-(phenyldimethylsilyl) ketones, the oxidation of which gave the corresponding optically active β-hydroxy ketones in high yields.

Reaction of phenyl(trimethylsilyl)silylene with chloromethanes; Insertion into C-Cl bond and abstraction of chlorine and HCl

Photolysis of tris(trimethylsilyl)phenylsilane in chloromethanes, ClnCX(4-n), (n = 1-4, X = H, alkyl, and Cl) produced phenyl(trimethylsilyl)silylene as a major intermediate, which afforded three types of products: 1,1-dichloro-1-phenyltrimethyldisilane via abstraction of two chlorine atoms, 1-alkyl-1-chloro-1-phenyltrimethyl-disilane via insertion into the C-Cl bond, and 1-chloro-1-phenyl-2,2,2-trimethyldisilane via abstraction of HCl.Possible reaction mechanisms for the formation of these products were discussed based on initial formation of an 1,2-zwitterionic intermediate.A small amount of a radical-reaction product, 2-chloro-2-phenyl-hexamethyltrisilane, and a product considered to be a cyclohexadienyl derivative were detected in all cases as minor products.