57529-77-8Relevant academic research and scientific papers
Basic derivatives of 6,7 dihydroindolo[1,7 ab][1]benzazepine and 6H indolo[7,1 cd][1,5]benzoxazepine as potential antidepressant agents
Toscano,Grisanti,Fioriello,Seghetti,Bianchetti,Bossoni,Riva
, p. 208 - 213 (1976)
Basic derivatives of 6,7 dihydroindolo[1,7-ab][1] benzazepine and 6H-indolol[7,1-cd][1,5]benzoxazepine incorporating the imipramine basic side chain were synthetized and screened for antidepressant activity in mice. With few exceptions, the compounds unsubstituted at C-2 antagonized reserpine induced ptosis and hypothermia showing negligible anticholinergic and antihistaminic properties. The compound 1-[2-(N-methyl-N-benzylamino)ethyl]6,7 dihydroindolo[1,7-ab][1]benzazepine had the highest toxicity activity ratio.
