Basic derivatives of 6,7 dihydroindolo[1,7 ab][1]benzazepine and 6H indolo[7,1 cd][1,5]benzoxazepine as potential antidepressant agents

Article abstract of DOI:10.1021/jm00224a003

Basic derivatives of 6,7 dihydroindolo[1,7-ab][1] benzazepine and 6H-indolol[7,1-cd][1,5]benzoxazepine incorporating the imipramine basic side chain were synthetized and screened for antidepressant activity in mice. With few exceptions, the compounds unsubstituted at C-2 antagonized reserpine induced ptosis and hypothermia showing negligible anticholinergic and antihistaminic properties. The compound 1-[2-(N-methyl-N-benzylamino)ethyl]6,7 dihydroindolo[1,7-ab][1]benzazepine had the highest toxicity activity ratio.