57538-27-9Relevant articles and documents
A novel and practical method for the synthesis of dinotefuran through Michael addition of nitromethane to diethyl maleate
Li, Haifeng,Wang, Lailai
, p. 336 - 340 (2017/12/11)
A novel and practical synthesis of dinotefuran 1, featuring a new access to it from known key intermediate (tetrahydrofuran-3-yl)-methanamine 5, has been achieved through Michael addition reaction of nitromethane to diethyl maleate in 6 steps with 45.5% total yield. This synthesis is scalable and hence has high potential for application to further synthetic elaboration on such new neonicotinoid insecticide dinotefuran 1.
Production of compounds
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Paragraph 0050, (2017/12/01)
Provided is a method for producing a compound represented by formula (2), or a salt thereof, by reacting ammonia with formaldehyde so as to obtain a mixture that contains a compound represented by formula (8), and then mixing the obtained mixture that contains the compound represented by formula (8) with a compound represented by formula (1), or a salt thereof, in the presence of a base.
PROCESS FOR PRODUCTION OF O-METHYL-N-NITROISOUREA
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Page/Page column 5, (2008/12/04)
Disclosed is an industrially advantageous process for producing O-methyl-N-nitroisourea. Disclosed is a process for obtaining O-methyl-N-nitroisourea represented by the following chemical formula (1) or a salt thereof in a high yield by performing the nitration of O-methylisourea represented by the following chemical formula (2) or a salt thereof with nitrating agents in the presence of fuming sulfuric acid.