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5754-07-4

N-(3-carboxypropanoyl)-β-phenyl-α-alanine, also known as β-phenyl-β-alanine or β-phenyl-β-aminopropionic acid, is a synthetic amino acid derivative characterized by the presence of a phenyl ring attached to the β-carbon of the amino acid β-alanine. N-(3-carboxypropanoyl)-β-phenyl-α-alanine is formed by the condensation of β-alanine with malonic acid, resulting in a molecule that possesses a carboxylic acid group at the 3-position of the propanoyl chain. It is an important building block in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals due to its unique structural properties and reactivity. The compound is also of interest in the field of peptidomimetics, where it can be used to create novel bioactive molecules with potential applications in drug discovery.

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  • 5754-07-4 Structure

  • Basic information

    1. Product Name: N-(3-carboxypropanoyl)-β-phenyl-α-alanine
    2. Synonyms: N-(3-carboxypropanoyl)-β-phenyl-α-alanine
    3. CAS NO:5754-07-4
    4. Molecular Formula:
    5. Molecular Weight: 265.266
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 5754-07-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(3-carboxypropanoyl)-β-phenyl-α-alanine(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-carboxypropanoyl)-β-phenyl-α-alanine(5754-07-4)
    11. EPA Substance Registry System: N-(3-carboxypropanoyl)-β-phenyl-α-alanine(5754-07-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 5754-07-4(Hazardous Substances Data)

5754-07-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5754-07-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,5 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5754-07:
(6*5)+(5*7)+(4*5)+(3*4)+(2*0)+(1*7)=104
104 % 10 = 4
So 5754-07-4 is a valid CAS Registry Number.

5754-07-4Relevant articles and documents

Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents

Abram, Micha?,Kamiński, Krzysztof,Kamiński, Rafa? M.,Latacz, Gniewomir,Lubelska, Annamaria,Mogilski, Szczepan,Rapacz, Anna

, p. 1996 - 2008 (2020)

We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the maximal electroshock (MES) test, the pentylenetetrazole-induced seizures (scPTZ), and the 6 Hz (32 mA) seizures. Compound 22 showed the most potent anticonvulsant activity (ED50 MES = 23.7 mg/kg, ED50 6 Hz (32 mA) = 22.4 mg/kg, ED50 scPTZ = 59.4 mg/kg). In addition, 22 revealed potent efficacy in the formalin-induced tonic pain. These in vivo activities of 22 are likely mediated by several targets and may result from the inhibition of central sodium/calcium currents and transient receptor potential vanilloid 1 (TRPV1) receptor antagonism. Finally, the lead compound 22 revealed drug-like absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) properties in the in vitro assays, making it a potential candidate for further development in epilepsy and neuropathic pain indications.

ACYLATION OF STEROID ALCOHOLS WITH 3-CARBOXYPROPANAMIDO ACIDS

Volovel'skii, L. N.,Rastrepina, I. A.,Popova, N. V.,Koryukina, V. N.,Kustova, S. P.

, p. 657 - 660 (2007/10/02)

Using N-(3-carboxypropanoyl)-β-phenyl-α-alanine as a model it has been established that when steroid alcohols are esterified with 3-carboxypropanamido acids, the carboxy group of the succinic acid residue takes part in the esterification reaction.In order

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