57560-83-5Relevant academic research and scientific papers
Synthesis of new 3,4-di-and 1,2,3,4-tetrahydroquinazolin-4-one derivatives and X-ray diffraction study of crystal solvates of 3-methylsulfonylamino-2-(2- methylsulfonylaminophenyl)-1,2,3,4-tetrahydroquinazolin-4-one
Ukhin,Kuz'mina
, p. 1229 - 1238 (2008/02/02)
The reactions of hydrazide, mesyl hydrazide, succinyl hydrazide, and maleyl hydrazide of anthranilic acid with carbonyl compounds were studied, and new di-and tetrahydroquinazolin-4-one derivatives were prepared. The structure of one reaction product, viz., 3-methylsulfonylamino-2-(2- methylsulfonylaminophenyl)-1,2,3,4-tetrahydroquinazolin-4-one, was established by X-ray diffraction study of two crystal solvates of this compound. The characteristic features of the crystal packings of these solvates are discussed. Springer Science+Business Media, Inc. 2006.
Transformations of N'-Anthranyloylhydrazides of Dicarboxylic Acids: Synthesis of Quinazolin-4-one Derivatives
Shemchuk
, p. 534 - 537 (2007/10/03)
By heating of the appropriate N'-anthraniloylhydrazides of dicarboxylic acids with acetic anhydride 3-succinimido-, 3-phthalimido-, and 3-glutarimido-2-methylquinazolin-4-ones have been obtained. The result of the reaction is not affected by the amount of acetic anhydride. The same compounds were synthesized independently from 3-amino-2-methylquinazolin-4-one and anhydrides of dicarboxylic acids. Alkaline hydrolysis of the obtained compounds is followed by opening of the imide cycle. On boiling of N'-anthraniloylhydrazides of succinic and phthalic acids in ethylene glycol 3,4-dihydropyridazino[2,3-c]-quinazoline-2,10-dione and phthalazino[2,3-c]quinazoline-2,12-dione, are formed, respectively.
