57573-32-7

Basic information

• Product Name: (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide
• CAS NO: 57573-32-7
• Molecular Formula: C₁₀H₁₃ClNOPS
• Molecular Weight: 261.7081
• Mol File: 57573-32-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 329.715°C at 760 mmHg
• Flash Point: 153.206°C
• Density: 1.33g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide(57573-32-7)
• EPA Substance Registry System: (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide(57573-32-7)

Safety Data

• Hazardous Substances Data: 57573-32-7(Hazardous Substances Data)

Upstream product

• 3982-91-0 trichlorothiophosphine 
• 90-82-4 pseudoephedrine 
• 50-98-6 ephedrine hydrochloride 

Downstream Products

• 124755-99-3 C₁₀H₁₃NOPS 
• 28080-20-8 C₁₀H₁₃ClNOPS^(1-) 
• 66193-94-0 (R)-Thiophosphoric acid O-isopropyl ester O'-methyl ester O''-((1R,2S)-2-methylamino-1-phenyl-propyl) ester 
• 66193-94-0 (S)-Thiophosphoric acid O-isopropyl ester O'-methyl ester O''-((1R,2S)-2-methylamino-1-phenyl-propyl) ester 
• 133076-12-7 (2R,4S,5R)-2-[1-(2-[1,3]Dioxan-2-yl-4,6-dimethoxy-phenyl)-4,5-dimethoxy-naphthalen-2-ylmethoxy]-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-sulfide 
• 57573-35-0 (4S)-2-isopropoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide 
• 57573-34-9 (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide 
• 57573-33-8 (2R,4S,5R)-2-methoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide 

Relevant articles and documents

Novel methods for ester detoxication

This invention relates to a method for detoxication of inorganic or organic esters including OP nerve agents, cocaine, and respective analogs. More specifically, this invention pertains to the treatment of potentially neurotoxic esters or other ester grou

Intermolecular effects on the radiogenic formation of electron-capture phosphorus-centered radicals. A single-crystal ESR study of diastereoisomeric precursors

ESR experiments on X-irradiated single crystals of the 2R,4S,5R and 2S,4S,5R diastereoisomers of 2-chloro3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine 2-sulfide reveal that the yield of radiogenic electron-capture reactions in the solid state strongly depends on intermolecular interactions in the crystal. In the present case a high yield of P-Cl three-electron-bond phosphoranyl radical anions is found in crystals of the 2R,4S,5R isomer, whereas no radical formation can be detected for the 2S,4S,5R isomer. An analysis of nonbonded interactions with neighboring molecules reveals that the geometry relaxation necessary for the radical stabilization is easily accommodated in crystals of the 2R,4S,5R isomer but not in the 2S,4S,5R isomer, explaining the observed difference in electron-capture efficiency. Experiments on radical formation in a MeTHF host matrix give further insight into the importance of the environment on radiogenic radical formation. The possible concurrent effect of the matrix on the electronic configuration and spin density distribution of the resulting phosphoranyl radical is discussed.