5759-63-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Methyl-6-methylaminouracil is used as a building block for the synthesis of various drugs and pharmaceutical products due to its unique chemical structure and potential biological activities.
Used in Anticancer Research:
In the field of oncology, 3-Methyl-6-methylaminouracil is studied for its potential as an anti-cancer agent, with its capacity to modulate enzyme activity and exhibit pharmacological effects that may contribute to the development of new cancer therapeutics.
Used in Enzyme Modulation:
3-Methyl-6-methylaminouracil is also utilized in the study and development of enzyme modulators, given its ability to interact with enzymes and potentially influence their activity, which can be instrumental in the treatment of various diseases and conditions.
Overall, 3-Methyl-6-methylaminouracil holds promise in advancing the development of new therapeutic agents and pharmaceuticals, particularly in the areas of cancer treatment and enzyme-related drug discovery.

InChI:InChI=1/C6H9N3O2/c1-7-4-3-5(10)9(2)6(11)8-4/h3,7H,1-2H3,(H,8,11)

Upstream product

• 4318-56-3 3-methyl-6-chlorouracil 
• 74-89-5 methylamine 

Downstream Products

• 75427-39-3 C₂₀H₂₄N₆O₄ 
• 75427-35-9 5,5'-p-chlorophenylmethylenebis(6-methylamino-3-methyluracil) 
• 75444-92-7 C₁₉H₂₂N₆O₄ 
• 75427-41-7 C₁₉H₂₂N₆O₅ 
• 75427-40-6 C₂₀H₂₄N₆O₅ 
• 75427-34-8 C₁₉H₂₁ClN₆O₄ 
• 75427-37-1 4-[Bis-(3-methyl-6-methylamino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-methyl]-benzonitrile 
• 75427-52-0 3,10-Dimethyl-8-hydroxy-2,4(3H,10H)-pyrimido<4,5-b>chinolindion 
• 85103-12-4 3,6,8-Trimethyl-7-phenyl-8H-pyrido[2,3-d]pyrimidine-2,4-dione 
• 85103-14-6 ethyl 2,3,4,8-tetrahydro-3-methyl-2,4-dioxopyrido-7-phenyl-8-methyl<2,3-d>pirimidine-6-carboxylate 
• 98629-74-4 5,5'-<4'-nitro-1,1'-biphenyl>-4-ylmethylenebis(6-methylamino-3-methyluracil) 
• 75427-36-0 C₁₉H₂₀Cl₂N₆O₄ 
• 75427-38-2 C₂₀H₂₄N₆O₄ 
• 5770-19-4 5-Nitroso-4-methylamino-1-methyl-uracil 

Relevant academic research and scientific papers

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).

3-ALKYL-6-METHYL-5,7-DIOXO-4,5,6,7-TETRAHYDRO-1,2,3-TRIAZOLOPYRIMIDINES AND THEIR ALKYLATIONS

Alkylation of 3-alkyl-6-methyl-5,7-dioxo-4,5,6,7-tetrahydro-1,2,3-triazolopyrimidines I with alkyl halides in dimethylformamide in the presence of potassium carbonate, or by analogous alkylation of sodium salts of compounds I afforded the respectiv

Autorecycling Oxidation of Alcohols Catalysed by Pyridopyrimidines as an NAD(P)(1+) Model

Two kinds of pyridopyrimidines as new NAD-type redox catalysts, 3,7,10-trisubstituted pyridodipyrimidine-2,4,6,8(1H,3H,7H,10H)-tetraones 6 and 3,8,10-trisubstituted pyridodipyrimidine-2,4,6(3H,7H,10H)-triones 7, have been synthesized by the condensation of 6-(substituted-amino)uracils 9 and 6-(substituted-amino)-2-phenylpyrimidin-4(3H)-ones 11 with appropriate 6-chloro-5-formyluracils 12 or 2,4,6-trichloropyrimidine-5-carbaldehyde 13 in dimethylformamide (DMF) or acetic acid.Compounds 6 and 7 have been found to oxidize a variety of alcohols under neutral conditions (in the absence of base) to yield the corresponding carbonyl compounds, catalytically with a markedly high turnover number.The oxidation yields were promoted remarkably depending upon the presence of lipophilic substituents, particularly due to the presence of longer alkyl groups at the 10-position.These catalysts are so stable that the oxidation reaction proceeds until the substrate is exhausted.