576-02-3

Usage

Uses

Used in Pharmaceutical Industry:
MARITIMETIN is used as a pharmaceutical compound for its potential therapeutic applications. Its hydroxy groups enable interactions with biopolymers and macromolecules, making it a promising candidate for the development of new drugs and treatments.
Used in Cosmetic Industry:
MARITIMETIN is used as an active ingredient in the cosmetic industry for its potential benefits to skin health and appearance. MARITIMETIN's ability to interact with biopolymers and macromolecules may contribute to its use in skincare products, potentially offering anti-aging, moisturizing, or protective properties.
Used in Research and Development:
MARITIMETIN is used as a research compound for studying its chemical properties and potential applications in various fields. Its unique structure and functional groups make it an interesting subject for scientific investigation, which could lead to the discovery of new uses and applications in the future.

InChI:InChI=1/C15H10O6/c16-9-3-1-7(5-11(9)18)6-12-13(19)8-2-4-10(17)14(20)15(8)21-12/h1-6,16-18,20H/b12-6-

Upstream product

• 6272-27-1 6,7-dihydroxybenzofuran-3[2H]-one 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 134955-54-7 (Z)-7-O-β-D-glucopyranosyl-6,7,3',4'-tetrahydroxyaurone 
• 490-54-0 (Z)-6-O-β-D-glucopyranosyl-6,7,3',4'-tetrahydroxyaurone 
• 17345-68-5 ω-chloro-2,3,4-trihydroxyacetophenone 
• 87-66-1 2-hydroxyresorcinol 
• 134955-55-8 (Z)-6-O-(6-O-p-coumaroyl-β-D-glucopyranosyl)-6,7,3',4'-tetrahydroxyaurone 

Relevant academic research and scientific papers

Design, synthesis and biological activities of dihydroaurones

To widen aurones applicability in achromatic food and cosmetic applications, a series of dihydroaurones were designed to mimic natural aurones as well as synthetic aurones. Dihydroaurones have been synthesized from the corresponding aurones by hydrogenation. These dihydroaurones and their corresponding aurones were screened for antioxidant, anti-inflammatory and tyrosinase enzyme inhibitory activity. Synthesized dihydroaurones (3b-f) displayed superior antioxidant activity in superoxide free radical scavenging assay than the standard gallic acid. Dihydroaurones (3b-f) also exhibited significant tyrosinase enzyme inhibitory activity and two dihydroaurones (3h, 3j) showed promising 5-lipoxygenase inhibitory activity.

Aurones as new porcine pancreatic α-amylase inhibitors

Background: Aurones, (Z)-2-benzylidenebenzofuran-3-one derivatives, are naturally-occurring structural isomers of flavones, with promising pharmacological potential. Methods: In this study, the structural requirements for the inhibition of porcine pancreatic α-amylase by hydroxylated or methoxylated aurone derivatives were investigated by assessing their in vitro biological activities against porcine pancreatic α-amylase. Results: The structure-activity relationship of these inhibitors based on both in vitro and in silico findings showed that the hydrogen bonds between the OH groups of the A or B ring of (Z)-benzylidenebenzofuran-3-one derivatives and the catalytic residues of the binding site are crucial for their inhibitory activities. Conclusion: It seems that the OH groups in aurones inhibit α-amylase in a manner similar to that of OH groups in flavones and flavonols.

"On water" synthesis of aurones: First synthesis of 4,5,3',4',5'-pentamethoxy-6-hydroxyaurone from Smilax riparia

A simple and green method for the synthesis of aurones by condensation of benzofuranone with aromatic aldehyde in neat water has been developed. The main advantages of this protocol include good yields, absence of catalyst, reagent, organic solvent, work-up and chromatographic purification. 4,5,3',4',5'-Pentamethoxy-6-hydroxyaurone, isolated from Smilax riparia was synthesized for the first time from 3-benzyloxy-4,5-dimethoxybenzaldehyde in five steps. {figure presented}.

Synthesis and antioxidative activity of 3′,4′,6,7- tetrahydroxyaurone, a metabolite of Bidens frondosa

3′,4′,6,7-Tetrahydroxyaurone (1a), an aurone isolated from Bidens frondosa, and five analogues (1b-1f) were synthesized from pyrogallol in three steps. The antioxidative activity of 1a-1f was determined by the superoxide free radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging methods.