57626-32-1

Usage

Chemical structure

The compound consists of a thiazole ring with an attached amino group and a phenyl ring with an attached ketone group.

Common uses

It is commonly used in the pharmaceutical industry and has potential applications in drug development and medicinal chemistry.

Biological activity

The thiazole ring and the amino group are important for the compound's biological activity and potential as a drug candidate.

Pharmacological effects

The chemical may have various pharmacological effects, including antimicrobial, antifungal, and antiproliferative properties, making it an interesting target for further research and exploration in the field of drug discovery.

InChI:InChI=1/C11H10N2OS/c12-11-13-9(7-15-11)6-10(14)8-4-2-1-3-5-8/h1-5,7H,6H2,(H2,12,13)

Upstream product

• 57626-31-0 1-phenyl-4-bromo-1,3-butanedione 
• 17356-08-0 thiourea 
• 98-88-4 benzoyl chloride 
• 52804-68-9 4-hydroxy-1-phenylbut-2-yn-1-one 
• 1190928-72-3 4-bromo-1-phenylbut-2-yn-1-one 

Downstream Products

• 26175-40-6 4-phenethyl-thiazol-2-ylamine 
• 134260-00-7 2-amino-4-(β-hydroxy-β-phenylethyl)thiazole 

Relevant academic research and scientific papers

Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-α]pyrimidin-5-ones

A new synthesis of 2-aminothiazoles and 5H-thiazolo[ 3,2-α]pyrimidin- 5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thiopyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields. Georg Thieme Verlag Stuttgart.

Imidazothiazole derivatives. XI. Modulation of the CD2-receptor of human T trypsinized lymphocytes by several imidazothiazoles

About 40 substituted imidazothiazoles were obtained in order to study their in vitro immunological effect on the modulation of the expression of human T trypsinized lymphocytes by the CD2 receptor.A synthetic program was developed to introduce either an oxygenated function, such as ester (11, 14), acid (12) and arylketonic groups (9, 13, 15), or two groups, such as an aryl and an ester (1, 6, 8), an acid (3, 7) or a hydrazide (2).These compounds were examined by an E-rosette-forming-cell test, and display a positive drug efficacity index, suggesting a regeneration effect on the expression of CD2 receptors.The following structural parameters are favourable: an aryl moiety on the C-6 with a methoxy or nitro group: and an ethyl ester on the C-3, a double bond to the 2,3-position (the 5,6-position is ineffective).Acid and hydrazide functions or the loss of phenyl group on the C-6 decrease this activity.If the aryl group is on the C-3 or C-2 side chain, the activity is weaker and more so for the latter.However, the most interesting derivatives are less immunostimulating than levamisole hydrochloride. immunomodulator / imidazothiazole / human T lymphocyte / CD2 receptor