57631-27-3Relevant academic research and scientific papers
Synthetic studies on CP-225,917 and CP-263,114: Concise synthesis of the bicyclic core using an intramolecular Mukaiyama aldol reaction
Armstrong, Alan,Critchley, Trevor J.,Gourdel-Martin, Marie-Edith,Kelsey, Richard D.,Mortlock, Andrew A.
, p. 1344 - 1350 (2007/10/03)
A concise synthesis of the bicyclo[4.3.1]dec-1(9)-en-10-one core of the natural products CP-225,917 and CP-263,114 is reported, employing an intramolecular Mukaiyama aldol cyclisation as a key step.
Synthesis of the bicyclo[4.3.1]decenone core of CP-225,917 and CP-263,114
Armstrong, Alan,Critchley, Trevor J.,Mortlock, Andrew A.
, p. 552 - 553 (2007/10/03)
The bicyclo[4.3.1]decenone core of the ras-farnesyl protein transferee inhibitors CP-225,917 and CP-263,114 is prepared in 6 steps from cyclohexanone. The key step is an intramolecular Mukaiyama aldol reaction.
