57641-34-6Relevant academic research and scientific papers
Nitrogen- and sulfur-containing models for metallo-enzymes. Part I. Synthesis and physical studies of 2(2-pyridyl)-1,3-dithioalkyl-2-propanols, 2(2-pyridyl)- and 2(2-imidazolyl)-1,3-dimercapto-2-propanols
Curtis, N. J.,Brown, R. S.
, p. 65 - 75 (2007/10/02)
Several compounds of the title class have been synthesized as small-molecule analogues for the metal-binding sites in such biochemical systems as ADH.The ligands containing pyridine and two thioethers do not bind divalent metals Co(2+), Zn(2+), Cu(2+), N
Hypocholesterolemic activity of 1,3 bis(substituted phenoxy) 2 propanones
Piantadosi,Hall,Wyrick,Ishaq
, p. 222 - 229 (2007/10/12)
A series of 1,3 bis (substituted phenoxy) 2 propanones was found to be active hypocholesterolemic agents at 10 mg/kg/day. The p chloro and p methyl substituted phenoxy compounds possess the highest activity. These compounds did not possess the estrogenic and antifertility activities of the related previously reported derivatives of the bis (β phenylethyl) ketone series. The 1,3 bis (p methylphenoxy) 2 propanone (7) also lowered serum triglycerides and glycerol which appeared to be due to increased levels of serum lipase and reduced activity of liver lipase. There was reduced incorporation of free fatty acids into complex lipids by the liver. Cholesterol was excreted faster in the treated animals.
