57664-51-4

Upstream product

• 26870-36-0 2-(4-hydroxyphenyl)benzo[b]furan 
• 104-77-8 3-diethylaminopropyl chloride 
• 100-07-2 4-methoxy-benzoyl chloride 
• 70340-04-4 (2-hydroxybenzyl)triphenylphosphonium bromide 
• 19234-04-9 2-(p-methoxyphenyl)-benzo[b]furan 

Downstream Products

• 1210059-52-1 2-[4'-(3-diethylaminopropoxy)phenyl]-3-(4-trifluoromethylbenzoyl)benzofuran 
• 1210059-50-9 2-[4'-(3-diethylaminopropoxy)phenyl]-3-(2-fluorobenzoyl)benzofuran 

Relevant academic research and scientific papers

Synthesis of fluorinated 2,3-disubstituted benzofurans potential β-amyloid aggregation inhibitors

A convenient synthesis of 2-[4'-(3-diethylaminopropoxy)phenyl]-3(2-fluorobenzoyl)benzofuran, 3-(4-fluorobenzoyl)- and 3-(4-trifluoromethylbenzoyl) derivatives, via the Suzuki cross-coupling reaction as the key transformation, is described.

A short synthesis of the β-amyloid (Aβ) aggregation inhibitor 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran.

A short and convenient synthesis of 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran, an inhibitor of the aggregation of β-amyloid, which is thought to be the underlying cause of Alzheimer's disease, is described.

Substituted benzofurans and benzothiophenes

The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.