57667-73-9

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 34001-56-4 1,3-dibenzyluracil 
• 1195-08-0 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 934365-24-9 C₂₃H₂₂N₂O₅ 
• 934365-26-1 dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate 
• 950692-66-7 C₂₃H₂₂N₂O₅ 
• 934365-25-0 ethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxypropionate 
• 934365-27-2 dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1-hydroxy-3-oxopropylphosphonate 
• 1466-67-7 1,3-dibenzylurea 

Relevant academic research and scientific papers

A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity

We have synthesized novel phosphonic acid analogues of β-diketo acids. Interestingly, the phosphonic acid isostere, 2, of our anti-HIV compound, 1, was an inhibitor of only the strand transfer step, in stark contrast to 1. Compound 2 had lower anti-HIV ac

DIKETO ACIDS WITH NUCLEOBASE SCAFFOLDS: ANTI-HIV REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE IN COMBINATION THERAPY

A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HFV and in the treatmen

Heterocyclic transformations. Part 7. Unprecedented transformations of 1,3-dialkyl-5-formyluracils to 1,3-dialkyl-7-hydroxyquinazolines

1,3-Dialkyl-5-formyluracil reacts with ethyl acetoacetate, acetylacetone, benzoylacetone, acetoacetamide and acetoacetanilide under phase transfer catalytic conditions to provide exclusively the annulation products: 6-substituted-1,3-dialkyl-7-hydroxyquinazolines or/and also 4-hydroxybenzamide derivatives.Similar reaction with cyanoacetamide provides 6-cyano-7-hydroxy-1,3-dimethylpyridopyrimidine.The reaction mechanism prevailing in these reactions has been rationalized.