5768-24-1

Basic information

• Product Name: pyridine-2,6-diylbis(phenylmethanone)
• Synonyms: (6-benzoyl-2-pyridinyl)(phenyl)methanone
• CAS NO: 5768-24-1
• Molecular Formula: C₁₉H₁₃NO₂
• Molecular Weight: 287.312
• Mol File: 5768-24-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 486.9°C at 760 mmHg
• Flash Point: 245.5°C
• Density: 1.202g/cm³
• Vapor Pressure: 1.24E-09mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: pyridine-2,6-diylbis(phenylmethanone)(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-2,6-diylbis(phenylmethanone)(5768-24-1)
• EPA Substance Registry System: pyridine-2,6-diylbis(phenylmethanone)(5768-24-1)

Safety Data

• Hazardous Substances Data: 5768-24-1(Hazardous Substances Data)

Upstream product

• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 
• 71-43-2 benzene 
• 626-05-1 2,6-Dibromopyridine 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 108-48-5 2,6-dimethylpyridine 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 108-86-1 bromobenzene 
• 2402-78-0 2,6-dichloropyridine 
• 7446-70-0 aluminium trichloride 
• 7719-09-7 thionyl chloride 
• 25726-04-9 phenylglyoxylyl chloride 
• 112170-37-3 2,6-bis(α-cyanobenzyl)pyridine 

Downstream Products

• 1357385-39-7 C₃₁H₂₃N₃ 
• 1236907-74-6 2,6-bis[1-phenyl-2-(2,4,6-tri-tert-butylphenyl)-2-phosphaethenyl]pyridine 
• 1236907-79-1 2-[1-phenyl-2-(2,4,6-tri-tert-butylphenyl)-2-phosphaethenyl]-6-benzoylpyridine 
• 301658-91-3 [(2,6-(2,6-(i-Pr)2-C₆H₃N=CPh)2C₅H₃N)FeCl₂] 
• 500117-10-2 (2,6-bis[1-((2,4,6-trimethylphenyl)-imino)benzyl]pyridine)dichloronickel(II) 
• 947414-97-3 C₂₇H₂₃N₃ 
• 853916-14-0 2,6-bis-(α-hydroxy-benzyl)-pyridine 

Relevant articles and documents

Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: Structure-activity relationship studies on their anti-proliferative and iron chelation efficacy

Thiosemicarbazone chelators represent an exciting class of biologically active compounds that show great potential as anti-tumor agents. Our previous studies demonstrated the potent anti-tumor activity of the 2'-benzoylpyridine thiosemicarbazone series. W

Aromatic and nonaromatic pyriporphyrins

Pyriporphyrins with three different orientations for the pyridine moiety have been prepared using a '3 + 1' strategy. The nonaromatic pyriporphyrins are stable so long as phenyl substituents are present at the meso-positions adjacent to the pyridine ring. An aromatic dihydropyriporphyrin with an external CO 2Ph protective group has also been prepared from 2,4- pyridinedicarbaldehyde.

Palladium-catalyzed carbonylative coupling of pyridine halides with aryl boronic acids

The carbonylative Suzuki cross-coupling of a variety of mono-iodopyridines and bromopyridines (1a,b, 3a-c, 5) catalyzed by palladium-phosphane systems has been studied to prepare benzoylpyridine derivatives (2, 4, 6). The selectivity and the rate of the reaction are highly dependent on the reaction conditions, i.e. nature of the palladium catalyst precursor, solvent, temperature and CO pressure. The main side-products arise from direct, non-carbonylative cross-coupling. Under optimized conditions, benzoylpyridines are recovered in high yields (80-95%). The order of reactivity decreases from iodo- to bromopyridines and from 2-, 4- to 3-substituted halopyridines. The reactivity of dihalopyridines has been investigated; 2,6-dibromopyridine (7) and 3,5-dibromopyridine (11) are selectively transformed into either the corresponding benzoyl-phenylpyridine (8, 12) or the corresponding dibenzoylpyridine (9, 13). Dissymmetric 2,5-dihalopyridines (15a,b) are transformed into 2-benzoyl-5-bromopyridine (16) or 2,5-dibenzoylpyridine (17) in high yields.