5768-24-1

Upstream product

• 7446-70-0 aluminium trichloride 
• 7719-09-7 thionyl chloride 
• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 
• 71-43-2 benzene 
• 626-05-1 2,6-Dibromopyridine 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 2402-78-0 2,6-dichloropyridine 
• 108-48-5 2,6-dimethylpyridine 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 108-86-1 bromobenzene 
• 25726-04-9 phenylglyoxylyl chloride 
• 112170-37-3 2,6-bis(α-cyanobenzyl)pyridine 

Downstream Products

• 500117-10-2 (2,6-bis[1-((2,4,6-trimethylphenyl)-imino)benzyl]pyridine)dichloronickel(II) 
• 1357385-39-7 C₃₁H₂₃N₃ 
• 1236907-74-6 2,6-bis[1-phenyl-2-(2,4,6-tri-tert-butylphenyl)-2-phosphaethenyl]pyridine 
• 1236907-79-1 2-[1-phenyl-2-(2,4,6-tri-tert-butylphenyl)-2-phosphaethenyl]-6-benzoylpyridine 
• 301658-91-3 [(2,6-(2,6-(i-Pr)2-C₆H₃N=CPh)2C₅H₃N)FeCl₂] 
• 947414-97-3 C₂₇H₂₃N₃ 
• 853916-14-0 2,6-bis-(α-hydroxy-benzyl)-pyridine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: Structure-activity relationship studies on their anti-proliferative and iron chelation efficacy

Thiosemicarbazone chelators represent an exciting class of biologically active compounds that show great potential as anti-tumor agents. Our previous studies demonstrated the potent anti-tumor activity of the 2'-benzoylpyridine thiosemicarbazone series. W

Palladium-N-heterocyclic carbene an efficient catalytic system for the carbonylative cross-coupling of pyridine halides with boronic acids

Carbonylative cross-coupling of different pyridyl halides with various boronic acids was studied using catalytic systems constituted of N-heterocyclic carbene type ligands and palladium. These systems easily obtained in situ from the corresponding imidazolium salt and palladium acetate appear more efficient toward bromopyridines than catalysts based on hindered and basic alkylphosphines such as tricyclohexylphosphine. Their higher efficiency was also evidenced by coupling using chloro- or dichloropyridines and chloroquinolines, which practically do not react with catalytic systems based on phosphines.

Aromatic and nonaromatic pyriporphyrins

Pyriporphyrins with three different orientations for the pyridine moiety have been prepared using a '3 + 1' strategy. The nonaromatic pyriporphyrins are stable so long as phenyl substituents are present at the meso-positions adjacent to the pyridine ring. An aromatic dihydropyriporphyrin with an external CO 2Ph protective group has also been prepared from 2,4- pyridinedicarbaldehyde.

Chelate bis(imino)pyridine cobalt complexes: Synthesis, reduction, and evidence for the generation of ethene polymerization catalysts by Li+ cation activation

Treatment of the bis(iminobenzyl)pyridine chelate Schiff-base ligand 8 (ligPh) with FeCl2 or CoCl2 yielded the corresponding (ligPh)MCl2 complexes 9 (Fe) and 10 (Co). The reaction of 10 with methyllithium or "butadiene-magnesium" resulted in reduction to give the corresponding (ligPh)Co(I)Cl product 11. Similarly, the bis(aryliminoethyl)pyridine ligand (ligMe) was reacted with CoCl2 to yield (ligMe)CoCl2 (12). Reduction to (ligMe)CoCl (13) was effected by treatment with "butadiene-magnesium". Complex 13 reacted with Li[B(C 6F5)4] in toluene followed by treatment with pyridine to yield [(ligMe)Co+-pyridine] (15). The reaction of the Co(II) complexes 10 or 12 with ca. 3 molar equiv of methyllithium gave the cobalt(I) complexes 16 and 17, respectively. Treatment of the (lig Me)CoCH3 (17) with Li[B(C6F5) 4] gave a low activity ethene polymerization catalyst. Likewise, complex 16 produced polyethylene (activity = 33 g(PE) mmol(cat)-1 h-1 bar-1 at room temperature) upon treatment with a stoichiometric amount of Li[B(C6F5)4]. A third ligand (ligOMe) was synthesized featuring methoxy groups in the ligand backbone (22). Coordination to FeCl2 and CoCl2 yielded the desired compounds 23 and 24. Reaction with MeLi gave (lig OMe)CoMe (25/26). Treatment of 25/26 with excess B(C 6F5)3 gave the η6-arene cation complex 27, where one Co-N linkage was cleaved. Activation of 25/26 with Li[B(C6F5)4] again gave a catalytically active species.

Palladium-catalyzed carbonylative coupling of pyridine halides with aryl boronic acids

The carbonylative Suzuki cross-coupling of a variety of mono-iodopyridines and bromopyridines (1a,b, 3a-c, 5) catalyzed by palladium-phosphane systems has been studied to prepare benzoylpyridine derivatives (2, 4, 6). The selectivity and the rate of the reaction are highly dependent on the reaction conditions, i.e. nature of the palladium catalyst precursor, solvent, temperature and CO pressure. The main side-products arise from direct, non-carbonylative cross-coupling. Under optimized conditions, benzoylpyridines are recovered in high yields (80-95%). The order of reactivity decreases from iodo- to bromopyridines and from 2-, 4- to 3-substituted halopyridines. The reactivity of dihalopyridines has been investigated; 2,6-dibromopyridine (7) and 3,5-dibromopyridine (11) are selectively transformed into either the corresponding benzoyl-phenylpyridine (8, 12) or the corresponding dibenzoylpyridine (9, 13). Dissymmetric 2,5-dihalopyridines (15a,b) are transformed into 2-benzoyl-5-bromopyridine (16) or 2,5-dibenzoylpyridine (17) in high yields.

Direct Synthesis of Benzoylpyridines from Chloropyridines via a Palladium-Carbene Catalyzed Carbonylative Suzuki Cross-Coupling Reaction

The use of N-heterocyclic carbene-type ligands with palladium catalysts allows the activation of chloropyridines and chloroquinoline towards carbonylative cross-coupling with phenylboronic acid for the synthesis of unsymmetrical biaryl ketones.

Polymerisation catalyst

A nitrogen containing transition metal complex having Formula (I), wherein M is Fe[II], Fe[III], Co[I], Co[II], Co[III], Mn[I], Mn[II], Mn[III], Mn[IV], Ru[II], Ru[III] or Ru[IV]; X represents an atom or group bonded to the transition metal M; T is the oxidation state of the transition metal M and b is the valency of the atom or group X; R1, R2, R3, R4, R5, R19, R20, R21, R22, R23, R24, R25, R26, R27 and R28 are independently selected from hydrogen, halogen, hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl; when any two or more of R1, R2, R3, R4 and R5 and are hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl or substituted heterohydrocarbyl, two or more can be linked to form one or more cyclic substituents, and at least one of R4 and R5 is a hydrocarbyl group having at least two carbon atoms.

TRANSITION METAL COMPOUNDS, CATALYSTS FOR THE PRODUCTION OF ALPHA-OLEFINS AND PROCESS THEREFOR

A transition metal compound represented by the general formula (1): or the general formula (2): wherein M, R1 to R15, R31 to R45, X and n are as defined in the specification. By using a catalyst comprising (A) the transition metal compound of the formula (1) or (2) containing a transition metal selected from the group consisting of elements of Groups 8 to 10 of the Periodic Table; (B) at least one compound selected from the group consisting of an organoaluminum compound (B-1), an ionic compound (B-2) capable of converting the transition metal compound into a cationic transition metal compound, a Lewis acid (B-3), and clay, clay mineral and an ion-exchangeable layer compound (B-4); and (C) an optional organometallic compound, α-olefins are efficiently produced with a less amount of by-products such as heavy components and waxes.

Palladium-catalyzed carbonylative cross-coupling reactions of pyridine halides and aryl boronic acids: A convenient access to α-pyridyl ketones

The proper choice of solvent, catalyst precursor and CO pressure enables the easy and selective transformation of mono- and dihalopyridines into phenyl pyridyl ketones in 81-95% yields.

Synthesis of poly(m-pyridylene-1,2-diphenylvinylene)

The synthesis by dehalogenating polycondensation and characterization of a new soluble conjugated polymer, poly(m-pyridylene-1,2-diphenylvinylene), DP-PPyV, is reported here. It shows good mechanical properties and a λmax = 330 nm. The maximum