57682-51-6Relevant academic research and scientific papers
Fluorinated quinazolones III: synthesis and CNS depressant activity of fluorinated quinazolone derivatives
Joshi,Singh,Mehta,Sharma,Gupta
, p. 1428 - 1430 (1975)
The synthesis of 2 allythio 3 (4' fluorophenyl) 5, 6, 7, 8 tetrafluoro 4 quinazolone, 2 n propylthio 3 (4' fluorophenyl) 5, 6, 7, 8 tetrafluoro 4 quinazolone, 3 (4' bromophenyl) 5, 6, 7, 8 tetrafluoro 2, 4 quinazolinedithione, and seven fluorinated 2 alkyl/phenyl 3 aryl 4(3H) quinazolones is described. The synthesized compounds were screened for CNS depressant activity using pentobarbital sleeping time, pentylenetetrazole convulsions, and the condition avoidance test as the parameters. Most of the screened compounds exhibited significant depressant activity.
