Fluorinated quinazolones III: synthesis and CNS depressant activity of fluorinated quinazolone derivatives

Article abstract of DOI:10.1002/jps.2600640843

The synthesis of 2 allythio 3 (4' fluorophenyl) 5, 6, 7, 8 tetrafluoro 4 quinazolone, 2 n propylthio 3 (4' fluorophenyl) 5, 6, 7, 8 tetrafluoro 4 quinazolone, 3 (4' bromophenyl) 5, 6, 7, 8 tetrafluoro 2, 4 quinazolinedithione, and seven fluorinated 2 alkyl/phenyl 3 aryl 4(3H) quinazolones is described. The synthesized compounds were screened for CNS depressant activity using pentobarbital sleeping time, pentylenetetrazole convulsions, and the condition avoidance test as the parameters. Most of the screened compounds exhibited significant depressant activity.