Journal of Pharmaceutical Sciences p. 1428 - 1430 (1975)
Update date:2022-08-05
Topics:
Joshi
Singh
Mehta
Sharma
Gupta
The synthesis of 2 allythio 3 (4' fluorophenyl) 5, 6, 7, 8 tetrafluoro 4 quinazolone, 2 n propylthio 3 (4' fluorophenyl) 5, 6, 7, 8 tetrafluoro 4 quinazolone, 3 (4' bromophenyl) 5, 6, 7, 8 tetrafluoro 2, 4 quinazolinedithione, and seven fluorinated 2 alkyl/phenyl 3 aryl 4(3H) quinazolones is described. The synthesized compounds were screened for CNS depressant activity using pentobarbital sleeping time, pentylenetetrazole convulsions, and the condition avoidance test as the parameters. Most of the screened compounds exhibited significant depressant activity.
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Doi:10.1021/jo00869a007
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