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N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine is a complex organic compound that features a benzyl group connected to a phenylmethylamine moiety through a benzotriazole linker. N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine is categorized under the bridged PhC1 compounds and is known for its potential applications in scientific research and pharmaceutical development.

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  • 57684-32-9 Structure
  • Basic information

    1. Product Name: N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine
    2. Synonyms: N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine;1-(1H-Benzotriazol-1-yl)-N,N-dibenzylmethanamine;1H-Benzotriazole-1-methanamine, N,N-bis(phenylmethyl)-
    3. CAS NO:57684-32-9
    4. Molecular Formula: C21H20N4
    5. Molecular Weight: 328.4103
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 57684-32-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine(57684-32-9)
    11. EPA Substance Registry System: N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine(57684-32-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 57684-32-9(Hazardous Substances Data)

57684-32-9 Usage

Uses

Used in Scientific Research:
N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine is utilized as a ligand for various metal catalysts, playing a crucial role in facilitating chemical reactions and improving their efficiency.
Used in Pharmaceutical Development:
N-((1H-benzo[d][1,2,3]triazol-1-yl)Methyl)-N-benzyl-1-phenylMethanaMine is also employed in the development of pharmaceuticals, where it may contribute to the creation of new drugs with potential therapeutic benefits. However, further research is necessary to fully understand its pharmacological activities and biological effects.

Check Digit Verification of cas no

The CAS Registry Mumber 57684-32-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,6,8 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 57684-32:
(7*5)+(6*7)+(5*6)+(4*8)+(3*4)+(2*3)+(1*2)=159
159 % 10 = 9
So 57684-32-9 is a valid CAS Registry Number.

57684-32-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(1H-Benzotriazol-1-yl)-N,N-dibenzylmethanamine

1.2 Other means of identification

Product number -
Other names N-(dibenzylaminomethyl)benzotriazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57684-32-9 SDS

57684-32-9Relevant articles and documents

NOVEL COMPOUNDS FOR THE TREATMENT OF PARASITIC INFECTIONS

-

Page/Page column 37, (2019/08/14)

The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding compositions, and methods and/or uses in therapy, for example in the treatment of parasitic infections such as malaria, in particular infection by

Synthesis of Gly-ψ[(Z)CFCH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic

Nadon, Jean-Fran?ois,Rochon, Kristina,Grastilleur, Sébastien,Langlois, Guillaume,Dao, Thi Thanh Hà,Blais, Véronique,Guérin, Brigitte,Gendron, Louis,Dory, Yves L.

, p. 40 - 49 (2017/03/08)

A new Leu-enkephalin peptidomimetic designed to explore the hydrogen bond acceptor ability of the third peptide bond has been prepared and studied. This new analog is produced by replacing the third amide of Leu-enkephalin with a fluoroalkene. An efficient and innovative synthesis of the corresponding dipeptide surrogate Fmoc-Gly-ψ[(Z)CFCH]-Phe-OH is described. The key step involves the alkylation of a tin dienolate from the less hindered face of its chiral sulfonamide auxiliary derived from camphor. Once its synthesis was complete, its incorporation into the peptidomimetic sequence was achieved on a solid support with chlorotrityl resin following the Fmoc strategy. The peptidomimetic was characterized using competition binding with [125I]-deltorphin I on membrane extracts of HEK293 cells expressing the mouse delta opioid receptor (DOPr) and based on its abilities to inhibit the electrically induced contractions of the mouse vas deferens and to activate the ERK1/2 signaling pathway in DRGF11/DOPr-GFP cells. Together with our previous observations, our findings strongly suggest that the third amide bond of Leu-enkephalin primarily acts as a hydrogen bond acceptor in DOPr. Consequently, this amide bond can be successfully replaced by an ester, a thioamide, or a fluoroalkene without greatly impacting the binding or biological activity of the corresponding analogs. The lipophilicity (LogD7.4) of the active analog was also measured. It appears that fluoroalkenes are almost as efficient at increasing the lipophilicity as normal alkenes.

HETEROCYCLIC COMPOUND

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Paragraph 0564; 0971; 0972, (2017/04/11)

The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.

Heterocyclic compound

-

Paragraph 0334, (2017/09/28)

本發明提供一種具有CDK8/19抑制活性之雜環化合物。本發明提供一種如下式代表之化合物(其中各代號均如本文之定義)或其鹽。 The present invention provides a heterocyclic compound possessing CDK8/19 inhibitory activity. The present invention provides a compound represented by the formula wherein each symbol is as defined herein, or a salt thereof.

HETEROARYL SUBSTITUTED NICOTINAMIDE COMPOUNDS

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Paragraph 0520, (2015/07/15)

Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is a heteroaryl selected from pyrazolyl, indolyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrazolo[3,4-b]pyridinyl, pyrazolo[3,4-d]pyrimidinyl, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridinyl, imidazo[4,5-b]pyridinyl, and purinyl, wherein said heteroaryl is substituted with Ra and Rb; and R1 and R2 are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.

DIHYDROIMIDAZO [ 1, 5-F] PTERIDINES AS POLO-LIKE KINASE INHIBITORS

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Page/Page column 17-20, (2010/04/06)

The present invention provides PLK inhibitors of the formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.

POLO-LIKE KINASE INHIBITORS

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Page/Page column 235-236, (2009/05/29)

Compounds of the following formula are provided for use with kinases: (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates use

Methods and fluorinated compositions for treating amyloid-related diseases

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Page/Page column 66-67, (2008/06/13)

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease. Also described are methods, compounds, pharmaceutical compositions and kits for detecting, diagnosing, monitoring and treating or preventing amyloid-related disease.

Synthesis of vinylogous β-amino esters from N-(N,N-dialkylaminoalkyl)benzotriazoles

Aurrecoechea, Jose M.,Fernandez, Alvaro,Gorgojo, Jose M.,Suero, Ruben

, p. 693 - 702 (2007/10/03)

Treatment of N-(N,N-dialkylaminoalkyl)benzotriazoles with 4- bromocrotonates in the presence of zinc provides a new route to 5-(N,N-dialkylamino)-2-alkenoate esters. This is formally the result of the γ-addition of zinc dienolate reagents to iminium catio

Synthesis of N-[1-(trialkylstannyl)alkyl]amides and -amines by the displacement of benzotriazoles with trialkylstannyllithiums

Pearson,Stevens

, p. 904 - 906 (2007/10/02)

Condensation of benzotriazole, an aldehyde, and either an amine or amide using the method of Katritzky gave N-[1-benzotriazol-1-yl)alkyl]amides and -amines, which were treated with tributylstannyllithium or trimethylstannyllithium to afford N-[1-(trialkylstannyl)alkyl]amides and -amines, respectively. These compounds are important precursors of nitrogen-substituted organolithium reagents.

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