57688-35-4

Usage

Uses

Used in Pharmaceutical Industry:
4-[3,5-BIS(TRIFLUOROMETHYL)PHENOXY]ANILINE is used as a building block in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-[3,5-BIS(TRIFLUOROMETHYL)PHENOXY]ANILINE is utilized as a component in the creation of agrochemicals, potentially enhancing crop protection and yield.
Used in Materials Science:
4-[3,5-BIS(TRIFLUOROMETHYL)PHENOXY]ANILINE is employed as a key component in materials science applications, where it may be instrumental in the fabrication of novel materials with specific properties.
Used in Disease and Aging Research:
4-[3,5-BIS(TRIFLUOROMETHYL)PHENOXY]ANILINE is studied as a potential inhibitor for lipid peroxidation, a process that plays a role in various diseases and the aging process, indicating its use in the development of therapeutic agents to combat these conditions.
Used in Polymer Production:
4-[3,5-BIS(TRIFLUOROMETHYL)PHENOXY]ANILINE is also considered for use as a flame-retardant additive in the production of polymers, which could improve the safety characteristics of the final polymer products.

InChI:InChI=1/C14H9F6NO/c15-13(16,17)8-5-9(14(18,19)20)7-12(6-8)22-11-3-1-10(21)2-4-11/h1-7H,21H2

Upstream product

• 586-78-7 para-nitrophenyl bromide 
• 100-00-5 4-chlorobenzonitrile 
• 349-58-6 3,5-bis-(trifluoromethyl)phenol 

Downstream Products

• 51754-23-5 N-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-3,5-dichloro-2,6-dihydroxy-benzamide 
• 51754-53-1 N-[4-(3,5-Bis-trifluoromethyl-phenoxy)-phenyl]-2,6-dihydroxy-3-nitro-benzamide 

Relevant academic research and scientific papers

Gas transport membranes based on novel optically active polyester/cellulose/ZnO bionanocomposite membranes

Abstract: In this paper, at first commercially available ZnO nanoparticles were modified with biodegradable nanocellulose through ultrasonic irradiation technique. Then, optically active bionanocomposite (BNCs) membranes composed of polyester (PE) and cellulose/ZnO BNCs are synthesized, as a novel process to enhance gas separation performance. The obtained PE/BNCs were characterized by Fourier transform-infrared spectroscopy, thermogravimetry analysis (TGA), X-ray powder diffraction, field emission-scanning electron microscopy, and transmission electron microscopy (TEM). TGA data indicated an increase thermal stability of the PE/BNCs in compared to the pure polymer. From TEM image of PE/BNCs, it can be found that the surface-modified ZnO with diametric size of less than 40?nm, uniformly dispersed in the obtained PE matrix. The results obtained from gas permeation experiments with a constant pressure setup showed that adding cellulose/ZnO to the polyester membrane structure increased the permeability of the membranes. From biodegradation test observed that the degradation occurred in a faster rate in the presence of cellulose/ZnO in the PE matrix. Graphical Abstract: [Figure not available: see fulltext.].

Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8

Endosomal toll-like receptors (TLRs) 7 and 8 recognize viral single-stranded RNAs, a class of imidazoquinoline compounds, 8-oxo-adenosines, 8-aminobenzodiazepines, pyrimidines, and guanosine analogues. Substantial evidence is present linking chronic inflammation mediated specifically by TLR7 to the progression of autoimmunity. We identified a new TLR7/8 dual inhibitor (1) and a TLR8-specific inhibitor (2) based on our previous screen targeting TLR8. Compound 1, bearing a benzanilide scaffold, was found to inhibit TLR7 and TLR8 at low micromolar concentrations. We envisioned making modifications on the benzanilide scaffold of 1 resulting in a class of highly specific TLR7 inhibitors. Our efforts led to the discovery of a new TLR8 inhibitor (CU-115) and identification of a TLR7/8 dual inhibitor (CU-72), bearing a distinct diphenyl ether skeleton, with potential for TLR7 selectivity optimization. Given the role of TLR8 in autoimmunity, we also optimized the potency of 2 and developed a new TLR8 inhibitor bearing a 1,3,4-oxadiazole motif.

PHTHALANILATE COMPOUNDS AND METHODS OF USE

The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to treat bacterial infections, or to inhibit or kill bacteria, either in vitro or in vivo.