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Usage

Uses

Used in Medicinal Chemistry:
5(4H)-Oxazolone, 4-[(3-chlorophenyl)methylene]-2-methylis used as a building block for the synthesis of various organic compounds and pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs and therapeutic agents.
Used in Drug Discovery:
5(4H)-Oxazolone, 4-[(3-chlorophenyl)methylene]-2-methylis used as a potential lead compound in drug discovery. Its chemical properties and potential biological activities make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Chemical Synthesis:
5(4H)-Oxazolone, 4-[(3-chlorophenyl)methylene]-2-methylis used as a reagent in the synthesis of various organic compounds. Its versatile structure allows for a wide range of chemical reactions, making it a valuable tool in the field of organic chemistry.
Used in Research and Development:
5(4H)-Oxazolone, 4-[(3-chlorophenyl)methylene]-2-methylis used as a subject of research and development in the field of chemistry and biology. Its unique properties and potential applications make it an interesting compound for scientists to study and explore further.

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 543-24-8 N-acetylglycine 

Downstream Products

• 138973-19-0 1,4-Bis(5'-(3-chlorobenzylidene)-2'-methyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 139597-05-0 N-{4-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 1070875-09-0 methyl 2-acetamido-3-(3-chlorophenyl)propanoate 
• 188896-02-8 (Z)-3-(3-Chloro-phenyl)-2-hydroxy-acrylic acid methyl ester 

Relevant academic research and scientific papers

Chiral bisphosphine ligands based on quinoline oligoamide foldamers: application in asymmetric hydrogenation

A series of chiral bisphosphine ligands were designed and synthesized based on single-handed quinoline oligoamide foldamers. The bisphosphine ligands can coordinate with Rh(cod)2BF4 in a 1 : 1 stoichiometry and the resulted chiral Rh(i) catalysts were applied in the asymmetric hydrogenation of α-dehydroamino acid esters, in which excellent conversions and promising levels of enantioselectivity were achieved.

An Atropos Biphenyl Bisphosphine Ligand with 2,2′-tert-Butylmethylphosphino Groups for the Rhodium-Catalyzed Asymmetric Hydrogenation of Enol Esters

This is an update of our previous work concerning the development of Atropos biphenyl bisphosphine ligands. An unexpected Atropos structural property was confirmed by single crystal X-ray diffraction and this result is consistent with the computational calculations described in our previous work. This P-stereogenic bisphosphine ligand possessing a biphenyl backbone and 2,2′-tert-butylmethylphosphino groups has been applied to the Rh-catalyzed asymmetric hydrogenation of enol esters, which has not been widely studied and can be used for the synthesis of several important bioactive compounds. Although there is room for further improvement in enantioselectivity, the results reported herein provide a further understanding of such types of ligands. (Figure presented.).

Cation-triggered switchable asymmetric catalysis with chiral aza-crownphos

An aza-crown ether, modified phosphoramidite ligand, has been designed and synthesized. The ON/OFF reversible switch of catalytic activity for its rhodium catalyst was thoroughly investigated in the asymmetric hydrogenation of dehydroamino acid esters modulated by host-guest interactions. In the OFF state, the catalyst is almost inactive (less than 1% conversion) because of the formation of an intermolecular sandwich complex by two aza-crown ether moities and the cationic rhodium metal center. In using alkali-metal-cations as the trigger, the catalytic activity was turned ON and consequently resulted in full conversions and excellent enantioselectivities (up to 98% ee).

Chemocontrolled reduction of aromatic α-ketoesters by NaBH4: Selective synthesis of α-hydroxy esters or 1,2-diols

α-Hydroxyesters 5a-g or diols 6a-g have been obtained in high yields by reduction of aromatic α-ketoesters 4 once or twice respectively by using NaBH4 as the reducer under suitable conditions. The use of a solvent that does not interact with the reagent allowed the double reduction to occur with only a slight excess of borohydride in very mild conditions.

Synthesis of substituted quinazolone derivatives as potential anti-HIV agents (part III)

Several 1-[2-phenyl-4(4H)-oxo-3-quinazolinyl]-2-methyl-4-arylidine -5-oxo-imidazolines (Va-1), 2-phenyl-3-(aroyl amino)-4(4H)-oxo quinazolines (Vla-I) and N1-2-methyl-4(4H)-oxo-3-quinazolinyl-N2-aryl-thioureas (Vlla-k), have been synthesised and tested for anti-HIV activity. The structures of these compounds have been established on the basis of elemental analysis and spectral data.