57699-90-8Relevant academic research and scientific papers
Mimicking a proline tripeptide with pyrazolidines and a cyclopentane linker
Vertesaljai, Peter,Lebedyeva, Iryna O.,Oliferenko, Alexander A.,Qi, Xin,Fu, Junjie,Ostrov, David A.,Asiri, Abdullah M.,Dennis Hall,Katritzky, Alan
, p. 6653 - 6655 (2015)
In this work the five-step assembly of a peptidomimetic structurally resembling Prolyl-Prolyl-Proline tripeptide is reported. Proline units are mimicked by two pyrazolidine rings connected to trans-1,2-cyclopentanedicarboxylic acid. The Pro-Pro-Pro mimetic resembles a tri-l-proline unit but with increased lipophilicity and structural constraints imposed by the linker.
CHEMOKINE RECEPTOR MODULATORS
-
, (2008/12/07)
The invention provides compounds of Formula (I) and pharmaceutical compositions comprising compounds of Formula (I). These compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers.
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors
Ahn, Jin Hee,Kim, Jin Ah,Kim, Hye-Min,Kwon, Hyuk-Man,Huh, Sun-Chul,Rhee, Sang Dal,Kim, Kwang Rok,Yang, Sung-Don,Park, Sung-Dae,Lee, Jae Mok,Kim, Sung Soo,Cheon, Hyae Gyeong
, p. 1337 - 1340 (2007/10/03)
A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 μM and ED50 value of 80
The Couple Pro/AzaPro: a Means of β-Turn Formation Control Synthesis and Conformation of Two AzaPro-containing Dipeptides
Lecocq, Alain,Boussard, Guy,Marraud, Michel,Aubry, Andre
, p. 5209 - 5212 (2007/10/02)
On the basis of two synthesized AzaPro-containing dipeptides, the conformational influence of the azaproline residue (a nitrogen atom is substituted for the Pro-CHα) on the β-turn occurrence was tested according to its relative position in the
