577-64-0 Usage
Uses
Used in Pharmaceutical Industry:
Asterric acid is used as an anti-angiogenic agent for its ability to inhibit the formation of new blood vessels, which is a critical process in the growth and metastasis of solid tumors. By targeting VEGF, Asterric acid has potential applications in the treatment of various types of cancer.
Used in Drug Delivery Systems:
Similar to Gallotannin, Asterric acid can also benefit from novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Utilizing carriers such as organic and metallic nanoparticles can improve the efficacy of Asterric acid in cancer treatment, particularly when targeting angiogenesis-related pathways.
Biological Activity
asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.
in vitro
previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].
IC 50
10 μm for et-1 binding to the eta receptor ofa10 cells
references
[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).
Check Digit Verification of cas no
The CAS Registry Mumber 577-64-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 577-64:
(5*5)+(4*7)+(3*7)+(2*6)+(1*4)=90
90 % 10 = 0
So 577-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H16O8/c1-8-4-11(19)14(16(20)21)12(5-8)25-15-10(17(22)24-3)6-9(18)7-13(15)23-2/h4-7,18-19H,1-3H3,(H,20,21)
