577-90-2

Upstream product

• 394-06-9 2-(4-fluoro-phenyl)-3-methyl-quinoline-4-carboxylic acid 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 462-06-6 fluorobenzene 
• 91-56-5 indole-2,3-dione 
• 5344-90-1 2-Aminobenzyl alcohol 
• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 

Relevant academic research and scientific papers

Iridium-Catalyzed Transfer Hydrogenation for Construction of Quinolines from 2-Aminobenzyl Alcohols with Enones in Water

Herein, we describe a method for the synthesis of functionalized quinolines from 2-aminobenzyl alcohols with -nsaturatedketones.This method exhibits tolerance to various functional groups and high efficiency, is environmentally benign, and can be performed on a gram scale. Control experiments suggest that this transformation is accomplished by iridium complex catalyzed transfer hydrogenation, which is then followed by Friedl nder cyclization. The results display that alkali is essential for the high selectivities of this catalytic system.

Highly Diastereo- And Enantioselective Ir-Catalyzed Hydrogenation of 2,3-Disubstituted Quinolines with Structurally Fine-Tuned Phosphine-Phosphoramidite Ligands

A highly diastereo- and enantioselective Ir-catalyzed hydrogenation of unfunctionalized 2,3-disubstituted quinolines, especially 3-alkyl-2-arylquinolines, has been realized. The success of this hydrogenation is ascribed to the use of a structurally fine-tuned chiral phosphine-phosphoramidite ligand with a (Sa)-3,3′-dimethyl H8-naphthyl moiety and (Rc)-1-phenylethylamine backbone. The hydrogenation displayed broad functional group tolerance, thus furnishing a wide range of optically active 2,3-disubstituted tetrahydroquinolines in up to 96% ee and with perfect cis-diastereoselectivity.