57700-01-3

Basic information

• Product Name: L-Leucine, N-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(phenylmethyl)hydrazino]carbonyl ]-, methyl ester
• CAS NO: 57700-01-3
• Molecular Formula: C20H31N3O5
• Molecular Weight: 393.483
• Mol File: 57700-01-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(phenylmethyl)hydrazino]carbonyl ]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(phenylmethyl)hydrazino]carbonyl ]-, methyl ester(57700-01-3)
• EPA Substance Registry System: L-Leucine, N-[[2-[(1,1-dimethylethoxy)carbonyl]-1-(phenylmethyl)hydrazino]carbonyl ]-, methyl ester(57700-01-3)

Safety Data

• Hazardous Substances Data: 57700-01-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 53370-84-6 N'-benzylhydrazinecarboxylic acid tert-butyl ester 
• 2748-02-9 L-leucine tert-butyl ester hydrochloride 
• 24469-50-9 t-butyl 3-benzylidenecarbazate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 30293-88-0 N-carbonyl-L-leucine methyl ester 

Downstream Products

• 1429433-32-8 Boc-AzaPhe-Leu-OH 
• 1429433-54-4 H-AzaPhe-Leu-OH hydrochloride 

Relevant articles and documents

Benzotriazole-mediated synthesis of aza-peptides: En route to an aza-leuenkephalin analogue

Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with α-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide 23b, and α-hydroxy-β-phenylpropionic acid 27 yielding, respectively, azatripeptides 24a-g, azatetrapeptides 25a,b, a hybrid azatripeptide with an oxyamide bond 26a, a hybrid azatetrapeptide with an ester bond 26b, and a hybrid azatripeptide with an ester bond 28. A new protocol for the synthesis of N-Pg-azatripeptides 33a,b and 35a,b, each containing a natural amino acid at the N-terminus, avoids the low coupling rates of the aza-amino acid residue and enables the solution-phase synthesis of an azaphenylalanine analogue of Leu-enkephalin 40.