57704-67-3Relevant academic research and scientific papers
Palladium-Catalyzed [3 + 2]-C-C/N-C Bond-Forming Annulation
Liu, Yang,Mao, Zhongyi,Pradal, Alexandre,Huang, Pei-Qiang,Oble, Julie,Poli, Giovanni
, p. 4057 - 4061 (2018)
The synthesis of bi- and tricyclic structures incorporating pyrrolidone rings is disclosed, starting from resonance-stabilized acetamides and cyclic α,β-unsaturated-γ-oxycarbonyl derivatives. This process involves an intermolecular Tsuji-Trost allylation/intramolecular nitrogen 1,4-addition sequence. Crucial for the success of this bis-nucleophile/bis-electrophile [3 + 2] annulation is its well-defined step chronology in combination with the total chemoselectivity of the former step. When the newly formed annulation product carries a properly located o-haloaryl moiety at the nitrogen substituent, a further intramolecular keto α-arylation can join the cascade, thereby forming two new cycles and three new bonds in the same synthetic operation.
Ir-catalyzed regio- and enantioselective decarboxylative allylic alkylations
He, Hu,Zheng, Xiao-Jian,Li, Yi,Dai, Li-Xin,You, Shu-Li
, p. 4339 - 4341 (2008/03/12)
[Ir(COD)Cl]2/phosphoramidite ligand 1a was found to be an efficient catalytic system, for the highly regio- and enantioselective decarboxylative alkylation of γ-substltuted allyl β-ketocarboxylates, affording the branched products with up to >99/1 branched-linear ratio and 96% ee.
