57711-77-0

Upstream product

• 3406-02-8 bis(phenylsulfonyl)methane 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 3561-67-9 bis(phenylthio)methane 

Downstream Products

• 1072831-54-9 (2S,3R)-2-benzyl-3-(4-methoxyphenyl)-4,4-bis(phenylsulfonyl)butan-1-ol 
• 1072831-49-2 (2S,3R)-3-(4-methoxyphenyl)-2-methyl-4,4-bis(phenylsulfonyl)butan-1-ol 
• 1312929-75-1 (2S,3R)-methyl 2-(diphenylmethyleneamino)-3-(4-methoxyphenyl)-4,4-bis(phenylsulfonyl)butanoate 
• 5765-29-7 E-2-(4-methoxybenzylidene)cyclohexanone 
• 3406-02-8 bis(phenylsulfonyl)methane 
• 1381793-49-2 2-(4-methoxyphenyl)-3-nitro-1,1-bis(phenylsulfonyl)propane 
• 1381793-53-8 2-(4-(dimethylamino)phenyl)-3-nitro-1,1-bis(phenylsulfonyl)propane 
• 57711-76-9 4-(dimethylamino)phenyl 2,2-bis(phenylsulfonyl)ethene 
• 1381793-51-6 ethyl 2-acetyl-3-(4-methoxyphenyl)-4,4-bis(phenylsulfonyl)butanoate 
• 1381793-52-7 3-(1-(4-methoxyphenyl)-2,2-bis(phenylsulfonyl)ethyl)pentane-2,4-dione 
• 1381793-50-5 diethyl 2-(1-(4-methoxyphenyl)-2,2-bis(phenylsulfonyl)ethyl)malonate 
• 1450630-41-7 C₂₁H₂₀O₅S₂ 
• 110490-05-6 2-(4-methoxyphenyl)maleonitrile 

Relevant academic research and scientific papers

Base-free Enantioselective C(1)-Ammonium Enolate Catalysis Exploiting Aryloxides: A Synthetic and Mechanistic Study

An isothiourea-catalyzed enantioselective Michael addition of aryl ester pronucleophiles to vinyl bis-sulfones via C(1)-ammonium enolate intermediates has been developed. This operationally simple method allows the base-free functionalization of aryl esters to form α-functionalized products containing two contiguous tertiary stereogenic centres in excellent yield and stereoselectivity (all ≥99:1 er). Key to the success of this methodology is the multifunctional role of the aryloxide, which operates as a leaving group, Br?nsted base, Br?nsted acid and Lewis base within the catalytic cycle. Comprehensive mechanistic studies, including variable time normalization analysis (VTNA) and isotopologue competition experiments, have been carried out. These studies have identified (i) orders of all reactants; (ii) a turnover-limiting Michael addition step, (iii) product inhibition, (iv) the catalyst resting state and (v) catalyst deactivation through protonation.

Stereoselective One-Pot Synthesis of cis-1,2-Dicyanoalkenes from 1,1-Bis(benzenesulfonyl)alkenes and KCN

An efficient synthesis of cis-1,2-dicyanoalkenes by the reaction of 1,1-bis(benzenesulfonyl)alkenes with KCN was developed. This reaction was conducted in the presence of tetrabutylammonium bromide and NH4Cl/K3PO4 under phase-transfer conditions. A series of cis-1,2-dicyanoalkenes were obtained in good to high yields. Further transformation of the obtained product allows for access to imide and dicarboxylic acid compounds.

Electrophilicities of bissulfonyl ethylenes

Kinetics of the reactions of bissulfonyl ethylenes with various carbanions, a sulfur ylide, and siloxyalkenes have been investigated photometrically at 20°C. The second-order rate constants have been combined with the known nucleophile- specific parameters N and sN for the nucleophiles to calculate the empirical electrophilicity parameters E of bissulfonyl ethylenes according to the linear free energy relationship log k(20°C)=s N(N+E). Structure-reactivity relationships are discussed, and it is shown that the electrophilicity parameters E derived in this work can be employed to define the synthetic potential of bissulfonyl ethylenes as Michael acceptors. Copyright