57719-96-7Relevant academic research and scientific papers
The catalytic asymmetric α-benzylation of aldehydes
List, Benjamin,Coric, Ilija,Grygorenko, Oleksandr O.,Kaib, Philip S. J.,Komarov, Igor,Lee, Anna,Leutzsch, Markus,Chandra Pan, Subhas,Tymtsunik, Andrey V.,Van Gemmeren, Manuel
, p. 282 - 285 (2014/01/17)
The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities. A sterically demanding proline derivative promotes the first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents. Racemic α-branched aldehydes react with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities. Copyright
NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 46, (2009/04/24)
A compound having the structure set forth in Formula (I): wherein the variables Y, R1, R2, R3, R4 and R5 are as defined herein. Compounds described herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of such compounds and pharmaceutical compositions to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity
HIV Integrase Inhibitors
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Page/Page column 73-74, (2009/10/17)
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
Stereoselective synthesis of 2,4-methanoproline homologues
Grygorenko, Oleksandr O.,Artamonov, Oleksiy S.,Palamarchuk, Gennady V.,Zubatyuk, Roman I.,Shishkin, Oleg V.,Komarov, Igor V.
, p. 252 - 258 (2007/10/03)
The stereoselective synthesis of 2-azabicyclo[2.2.1]heptane-1-carboxylic acid and 6-azabicyclo[3.2.1]octane-5-carboxylic acid, novel rigid bicyclic proline analogues, is reported. The synthesis was performed in five steps from the corresponding 2-cycloalk
PHOTOCLEAVAGE OF CARBON-TIN BOND ACTIVATED BY NEIGHBORING
Sato, Tadashi,Takezoe, Kohji
, p. 4003 - 4006 (2007/10/02)
β-Stannyl ketones underwent various types of reaction upon UV-irradiation, depending upon the substitution pattern of the substrate, and upon the solvent used.
