57742-93-5

Upstream product

• 14924-53-9 ethyl cyclobutylcarboxylate 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 1195-81-9 ethyl 1-(hydroxymethyl)cyclobutanecarboxylate 

Downstream Products

• 891188-48-0 ethyl 1-((4-methoxy-2,3,5-trimethylphenylamino)methyl)-cyclobutanecarboxylate 
• 891188-54-8 ethyl 1-((4-methoxy-2,3-dimethylphenylamino)methyl)cyclobutanecarboxylate 
• 1192181-61-5 (1-ethenylcyclobutyl)diphenylmethanol 
• 1192181-78-4 ethyl 4-(2-cyclobutylidenethyl)benzoate 
• 1333467-16-5 N-{4-(1-ethoxycarbonylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide 
• 1333467-00-7 N-{4-(1-ethoxycarbonylcyclobutyl)-2-phenylsulfonyl-2,3-butadienyl}-N-(2-propynyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of (2-arylethylidene)cyclobutanes by palladium-catalyzed reactions of aryl halides with homoallyl alcohols bearing a trimethylene group at the allylic position

Treatment of aryl bromides with homoallyl alcohols bearing a trimethylene group at the allylic position in the presence of cesium carbonate under palladium catalysis affords (2-arylethylidene) cyclobutanes selectively. The selective formation of the alkylidenecyclobutane skeleton results from regiospecific retroallylation of the homoallyl alcohols, which accompanies the transposition of the double bonds. Georg Thieme Verlag Stuttgart.

ORGANIC COMPOUNDS

The present invention provides novel organic compounds of Formula (I): methods of use, and pharmaceutical compositions thereof.

Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

The synthesis and SAR of a series of arylsulfonylpiperazine inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, selective, and orally bioavailable inhibitors demonstrating efficacy in a cynomolgus monkey ex vivo enzyme inhibition model.

Spiro derivatives as lipoxygenase inhibitors

The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful

ARYL SULFONAMIDE COMPOUNDS AND USES RELATED THERETO

The present invention provides Aryl Sulfonamide Compounds having the formula: (I); and prodrugs or pharmaceutically acceptable salts or prodrugs thereof. The Aryl Sulfonamide Compounds are useful for treating diabetes, obesity, and other diseases and disorders.