57743-16-5Relevant academic research and scientific papers
Asymmetric organocatalytic aza-michael reactions of isatin derivatives
?ari, Sergei,Metsala, Andrus,Kudrjashova, Marina,Kaabel, Sandra,J?rving, Ivar,Kanger, T?nis
, p. 875 - 886 (2015)
Isatin was activated by derivatization to a Schiff base with aniline and used as an aza-Michael donor in organocatalytic asymmetric reactions with symmetric and nonsymmetric unsaturated 1,4-diketones. After hydrolysis (in situ), the N-substituted isatins were obtained in high yields (up to >95%) with high enantioselectivity (up to 95%).
Remote activation of the nucleophilicity of isatin
Zari, Sergei,Kudrjashova, Marina,Pehk, Tonis,Lopp, Margus,Kanger, Tonis
supporting information, p. 1740 - 1743 (2014/04/17)
The concept of the remote activation of reactivity was first applied in asymmetric organocatalysis. An isatin 3-phenylimine derivative acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated 1,4-ketoesters, affording aza-Michael adducts in high enantiomeric purity and yield.
Synthesis and antibacterial activity of some 5-nitro-3-phenyliminoindol-2(3H)-ones and their N-mannich bases
Daisley,Shah
, p. 407 - 408 (2007/10/02)
The antimicrobial and antifungal activities of a series of 5-nitro-3-phenyliminoindol-2(3H)ones and their 1-piperidinomethyl analogues (N-Mannich bases) were investigated. Growth inhibition of Gram-positive bacteria was observed with little or no activity
