57743-22-3Relevant academic research and scientific papers
Synthesis and pharmacological activities of hydrazones, schiff and mannich bases of isatin derivatives
Sridhar, Seshaiah Krishnan,Ramesh, Atmakuru
, p. 1149 - 1152 (2001)
Schiff bases and phenyl hydrazone of isatins were prepared by reacting isatin and the appropriate aromatic primary amine/hydrazines. A new series of the corresponding N-mannich bases were synthesized by reacting them with formaldehyde and diphenylamine. T
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors
Gonzalez, Asensio,Quirante, Josefina,Nieto, Joan,Almeida, Maria Rosario,Saraiva, Maria Joao,Planas, Antoni,Arsequell, Gemma,Valencia, Gregorio
supporting information; experimental part, p. 5270 - 5273 (2010/03/24)
The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design. Among the series of isatin analogues prepared and tested, the nitro compound 1,3-dihydro-3-[(4-nitrophenyl)imino]-2H-indol-2-one (2r) is as potent as triiodophenol, which is one of the most active known TTR inhibitors. The E/Z stereochemistry of these molecules in solution, elucidated by 1H NMR, does not influence their biological activity. The compounds do not bind to the native tetrameric TTR suggesting that their inhibitory action is independent of the protein binding and stabilization.
Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives
Sridhar, Seshaiah Krishnan,Saravanan, Muniyandy,Ramesh, Atmakuru
, p. 615 - 625 (2007/10/03)
Schiff bases and hydrazones of substituted isatins (1-28) were prepared by reacting isatin and aromatic primary amines/hydrazines. A new series of the corresponding N-Mannich base (29-35) was synthesised by reacting them with formaldehyde and diphenyl ami
