57743-23-4Relevant academic research and scientific papers
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors
Gonzalez, Asensio,Quirante, Josefina,Nieto, Joan,Almeida, Maria Rosario,Saraiva, Maria Joao,Planas, Antoni,Arsequell, Gemma,Valencia, Gregorio
supporting information; experimental part, p. 5270 - 5273 (2010/03/24)
The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design. Among the series of isatin analogues prepared and tested, the nitro compound 1,3-dihydro-3-[(4-nitrophenyl)imino]-2H-indol-2-one (2r) is as potent as triiodophenol, which is one of the most active known TTR inhibitors. The E/Z stereochemistry of these molecules in solution, elucidated by 1H NMR, does not influence their biological activity. The compounds do not bind to the native tetrameric TTR suggesting that their inhibitory action is independent of the protein binding and stabilization.
Explorations on the total synthesis of the unusual marine alkaloid chartelline A
Sun, Cuixiang,Lin, Xichen,Weinreb, Steven M.
, p. 3159 - 3166 (2007/10/03)
In work directed toward a total synthesis of chartelline A (1a), a strategy was investigated to construct the 10-membered ring of this marine alkaloid via an intramolecular aldehyde/β-lactam cyclocondensation to form the macrocyclic enamide functionality.
Synthesis of Spiro-2,4'(1H)-diones
Rajopadhye, Milind,Popp, Frank D.
, p. 93 - 96 (2007/10/02)
The title compounds have been prepared by the cyclocondensation of 3-mercaptopropanoic acid with isatin-3-imines.The 1-benzyl derivatives have been synthesized by simultaneously reacting 1-benzylisatin, substituted anilines and 3-mercaptopropanoic acid.Ma
Synthesis and antibacterial activity of some 5-nitro-3-phenyliminoindol-2(3H)-ones and their N-mannich bases
Daisley,Shah
, p. 407 - 408 (2007/10/02)
The antimicrobial and antifungal activities of a series of 5-nitro-3-phenyliminoindol-2(3H)ones and their 1-piperidinomethyl analogues (N-Mannich bases) were investigated. Growth inhibition of Gram-positive bacteria was observed with little or no activity
