57743-37-0Relevant academic research and scientific papers
Synthesis and Some Reactions of 6H-Indolo[2,3-b]quinoxalines
Shulga,Shulga
, p. 2104 - 2108 (2021/02/09)
Abstract: 6H-Indolo[2,3-b]quinoxalines were synthesized by condensation of isatin and 5-nitroisatin with o-phenylenediamine. The alkylation of the title compounds with dimethyl sulfate gave the corresponding quaternary salts which were converted to perchlorates and oxidized with potassium hexacyanoferrate(III) to previously unknown 5-methyl-6H-indolo[2,3-b]quinoxalin-3-one and its 9-nitro derivative. Treatment of 6H-indolo[2,3-b]quinoxalin-3-ones with dimethyl sulfate afforded 3-methoxyindoloquinoxalinium salts which were demethylated by the action of hydrobromic acid at 130–140°C. The structure of the isolated compounds was confirmed by IR and NMR spectra and elemental analyses.
β-cyclodextrin mediated synthesis of indole derivatives: reactions of isatins with 2-amino(or 2-thiole)anilines by supramolecular catalysis in water
Shivhare, Km Neha,Siddiqui
, p. 52 - 61 (2018/10/24)
An elegant, mild, and straightforward strategy for the synthesis of indole derivatives have been accomplished by the biomimetic catalysis for the first time in water under neutral conditions. This supramolecular catalyst oriented methodology provides a sustainable and green protocol for the synthesis of 6H-indolo[2,3-b]quinoxalines and 3H-spiro[benzo[d]thiazole-2,3’-indolin]-2’-one by the reaction of isatin derivatives with 1,2-difunctionalized benzene using β-cyclodextrin (β-CD) as a recoverable and reusable supramolecular catalyst.
Impact of substituents on the isatin ring on the reaction between isatins with ortho-phenylenediamine
Dowlatabadi, Reza,Khalaj, Ali,Rahimian, Sima,Montazeri, Maedeh,Amini, Mohsen,Shahverdi, Ahmadreza,Mahjub, Elham
experimental part, p. 1650 - 1658 (2011/06/22)
The reaction of different substituted isatins with ortho-phenylenediamine in acetic acid has been investigated. While electron-donor substituents on isatin shift the reaction toward classical 6H-indolo[2,3-b]quinoxaline ring closure, electron-withdrawing
REACTION OF o-PHENYLENEDIAMINE WITH ISATINS
Ivashchenko, A. V.,Drushlyak, A. G.,Titov, V. V.
, p. 537 - 542 (2007/10/02)
It is shown that the reaction of o-phenylenediamine with isatins in the general case leads to mixtures of indoloquinoxalines, 3-(2'-aminophenyl)-2(1H)-quinoxalinones, and spiro.Spiro2H-benzimidazole-2,3'-in
